Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long?
ABSTRACT Little genomic data is available for typhoid fever from island nations, though the disease has a moderately high burden there. Sikorski et al. (M. J. Sikorski, T. H. Hazen, S. N. Desai, S. Nimarota-Brown, et al., mBio 13:e01920-22, 2022, https://doi.org/10.1128/mbio.01920-22) studied 306 Sa...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2022-12-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02426-22 |
| _version_ | 1811289947828649984 |
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| author | Arif Mohammad Tanmoy |
| author_facet | Arif Mohammad Tanmoy |
| author_sort | Arif Mohammad Tanmoy |
| collection | DOAJ |
| description | ABSTRACT Little genomic data is available for typhoid fever from island nations, though the disease has a moderately high burden there. Sikorski et al. (M. J. Sikorski, T. H. Hazen, S. N. Desai, S. Nimarota-Brown, et al., mBio 13:e01920-22, 2022, https://doi.org/10.1128/mbio.01920-22) studied 306 Salmonella enterica serovar Typhi genomes from the Samoan Islands collected during 1983 to 2020 and reported dominance of a rare genotype, 3.5.4, and no H58 (genotype 4.3.1). They found pansusceptibility of all isolates to three first lines of antimicrobial agents (ampicillin, chloramphenicol, and cotrimoxazole). This commentary evaluates the importance of these findings for the Samoan Islands and how they can help the global typhoid community. The microbial community in the environment and human gut could have played a role in the lack of antimicrobial resistance (AMR). However, drug-resistant strains may arrive soon at the island, as their international spread is common. Further investigation would help the global typhoid community to better understand the evolution of an isolated pathogen community and the effect of vaccination there. |
| first_indexed | 2024-04-13T04:04:21Z |
| format | Article |
| id | doaj.art-3e041dd8cfa44414a72f1c2406bd7a1c |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-04-13T04:04:21Z |
| publishDate | 2022-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-3e041dd8cfa44414a72f1c2406bd7a1c2022-12-22T03:03:23ZengAmerican Society for MicrobiologymBio2150-75112022-12-0113610.1128/mbio.02426-22Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long?Arif Mohammad Tanmoy0Child Health Research Foundation, Dhaka, BangladeshABSTRACT Little genomic data is available for typhoid fever from island nations, though the disease has a moderately high burden there. Sikorski et al. (M. J. Sikorski, T. H. Hazen, S. N. Desai, S. Nimarota-Brown, et al., mBio 13:e01920-22, 2022, https://doi.org/10.1128/mbio.01920-22) studied 306 Salmonella enterica serovar Typhi genomes from the Samoan Islands collected during 1983 to 2020 and reported dominance of a rare genotype, 3.5.4, and no H58 (genotype 4.3.1). They found pansusceptibility of all isolates to three first lines of antimicrobial agents (ampicillin, chloramphenicol, and cotrimoxazole). This commentary evaluates the importance of these findings for the Samoan Islands and how they can help the global typhoid community. The microbial community in the environment and human gut could have played a role in the lack of antimicrobial resistance (AMR). However, drug-resistant strains may arrive soon at the island, as their international spread is common. Further investigation would help the global typhoid community to better understand the evolution of an isolated pathogen community and the effect of vaccination there.https://journals.asm.org/doi/10.1128/mbio.02426-22typhoid feverantimicrobial resistanceH58typhoid conjugate vaccinemultidrug resistance |
| spellingShingle | Arif Mohammad Tanmoy Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long? mBio typhoid fever antimicrobial resistance H58 typhoid conjugate vaccine multidrug resistance |
| title | Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long? |
| title_full | Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long? |
| title_fullStr | Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long? |
| title_full_unstemmed | Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long? |
| title_short | Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long? |
| title_sort | salmonella enterica serovar typhi on an island no h58 no multidrug resistance but for how long |
| topic | typhoid fever antimicrobial resistance H58 typhoid conjugate vaccine multidrug resistance |
| url | https://journals.asm.org/doi/10.1128/mbio.02426-22 |
| work_keys_str_mv | AT arifmohammadtanmoy salmonellaentericaserovartyphionanislandnoh58nomultidrugresistancebutforhowlong |