A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family

A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family

A large group of bacterial virulence autotransporters including AIDA-I from diffusely adhering E. coli (DAEC) and TibA from enterotoxigenic E. coli (ETEC) require hyperglycosylation for functioning. Here we demonstrate that TibC from ETEC harbors a heptosyltransferase activity on TibA and AIDA-I, de...

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Bibliographic Details
Main Authors: Qing Yao, Qiuhe Lu, Xiaobo Wan, Feng Song, Yue Xu, Mo Hu, Alla Zamyatina, Xiaoyun Liu, Niu Huang, Ping Zhu, Feng Shao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
bacterial autotransporter
glycosyltransferase
bacterial pathogenesis
cryo-EM
enzyme complex
enzyme catalysis
Online Access:https://elifesciences.org/articles/03714

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