Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study
Objectives. Carotid bodies (CBs) play an important role in regulating sympathetic nervous system activity. Thus, they are likely to be enlarged in patients with certain cardiovascular and respiratory diseases. The aim of this case-control study was to verify this hypothesis using computed tomography...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2021-01-01
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| Series: | Radiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/9499420 |
| _version_ | 1798031730603458560 |
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| author | Sándor Csizmadia Gergely H. Fodor András Palkó Erika Vörös |
| author_facet | Sándor Csizmadia Gergely H. Fodor András Palkó Erika Vörös |
| author_sort | Sándor Csizmadia |
| collection | DOAJ |
| description | Objectives. Carotid bodies (CBs) play an important role in regulating sympathetic nervous system activity. Thus, they are likely to be enlarged in patients with certain cardiovascular and respiratory diseases. The aim of this case-control study was to verify this hypothesis using computed tomography angiography (CTA). Methods. We retrospectively analysed 141 CTAs including 16 controls, 96 patients with only hypertension (HT), 12 with HT and previous acute myocardial infarction (AMI), 9 with HT and heart failure (HF), and 8 with HT and chronic obstructive pulmonary disease (COPD). We assessed the data using analysis of variance, with p<0.05 indicating significance. Results. CB average areas in the controls were 2.31 mm2 (right side (RS)) vs. 2.34 mm2 (left side (LS)). CB size was significantly enlarged in patients with HT: 3.07 mm2 (RS) (p=0.019) vs. 2.91 mm2 (LS) (p=0.002). If AMI (RS: 3.5 mm2; LS: 3.44 mm2) or HF (RS: 4.01 mm2; LS: 4.55 mm2) was associated with HT, the CB size was even more enlarged. COPD did not affect CB size (RS: 2.40 mm2; LS: 2.29 mm2). Conclusions. Our data showed that certain diseases with increased activity of the sympathetic nervous system were associated with significantly enlarged CBs. |
| first_indexed | 2024-04-11T20:02:17Z |
| format | Article |
| id | doaj.art-3e060431eccb45a8912e780f7b586084 |
| institution | Directory Open Access Journal |
| issn | 2090-1941 2090-195X |
| language | English |
| last_indexed | 2024-04-11T20:02:17Z |
| publishDate | 2021-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Radiology Research and Practice |
| spelling | doaj.art-3e060431eccb45a8912e780f7b5860842022-12-22T04:05:32ZengHindawi LimitedRadiology Research and Practice2090-19412090-195X2021-01-01202110.1155/2021/94994209499420Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control StudySándor Csizmadia0Gergely H. Fodor1András Palkó2Erika Vörös3Affidea Hungary Ltd. Budapest, 44-46 Bókay János Street, Budapest H-1083, HungaryDepartment of Medical Physics and Informatics, University of Szeged, Faculty of General Medicine, 9 Korányi Alley, Szeged H-6725, HungaryDepartment of Radiology, University of Szeged, Faculty of General Medicine, 6 Semmelweis Street, Szeged H-6725, HungaryDepartment of Radiology, University of Szeged, Faculty of General Medicine, 6 Semmelweis Street, Szeged H-6725, HungaryObjectives. Carotid bodies (CBs) play an important role in regulating sympathetic nervous system activity. Thus, they are likely to be enlarged in patients with certain cardiovascular and respiratory diseases. The aim of this case-control study was to verify this hypothesis using computed tomography angiography (CTA). Methods. We retrospectively analysed 141 CTAs including 16 controls, 96 patients with only hypertension (HT), 12 with HT and previous acute myocardial infarction (AMI), 9 with HT and heart failure (HF), and 8 with HT and chronic obstructive pulmonary disease (COPD). We assessed the data using analysis of variance, with p<0.05 indicating significance. Results. CB average areas in the controls were 2.31 mm2 (right side (RS)) vs. 2.34 mm2 (left side (LS)). CB size was significantly enlarged in patients with HT: 3.07 mm2 (RS) (p=0.019) vs. 2.91 mm2 (LS) (p=0.002). If AMI (RS: 3.5 mm2; LS: 3.44 mm2) or HF (RS: 4.01 mm2; LS: 4.55 mm2) was associated with HT, the CB size was even more enlarged. COPD did not affect CB size (RS: 2.40 mm2; LS: 2.29 mm2). Conclusions. Our data showed that certain diseases with increased activity of the sympathetic nervous system were associated with significantly enlarged CBs.http://dx.doi.org/10.1155/2021/9499420 |
| spellingShingle | Sándor Csizmadia Gergely H. Fodor András Palkó Erika Vörös Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study Radiology Research and Practice |
| title | Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study |
| title_full | Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study |
| title_fullStr | Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study |
| title_full_unstemmed | Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study |
| title_short | Size of the Carotid Body in Patients with Cardiovascular and Respiratory Diseases Measured by Computed Tomography Angiography: A Case-Control Study |
| title_sort | size of the carotid body in patients with cardiovascular and respiratory diseases measured by computed tomography angiography a case control study |
| url | http://dx.doi.org/10.1155/2021/9499420 |
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