Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions.
Mechanical coherence of cell layers is essential for epithelia to function as tissue barriers and to control active tissue dynamics during morphogenesis. RhoA signaling at adherens junctions plays a key role in this process by coupling cadherin-based cell-cell adhesion together with actomyosin contr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-03-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1005411 |
| _version_ | 1819259706030424064 |
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| author | Rashmi Priya Guillermo A Gomez Srikanth Budnar Bipul R Acharya Bipul R Acharya Andras Czirok Alpha S Yap Zoltan Neufeld |
| author_facet | Rashmi Priya Guillermo A Gomez Srikanth Budnar Bipul R Acharya Bipul R Acharya Andras Czirok Alpha S Yap Zoltan Neufeld |
| author_sort | Rashmi Priya |
| collection | DOAJ |
| description | Mechanical coherence of cell layers is essential for epithelia to function as tissue barriers and to control active tissue dynamics during morphogenesis. RhoA signaling at adherens junctions plays a key role in this process by coupling cadherin-based cell-cell adhesion together with actomyosin contractility. Here we propose and analyze a mathematical model representing core interactions involved in the spatial localization of junctional RhoA signaling. We demonstrate how the interplay between biochemical signaling through positive feedback, combined with diffusion on the cell membrane and mechanical forces generated in the cortex, can determine the spatial distribution of RhoA signaling at cell-cell junctions. This dynamical mechanism relies on the balance between a propagating bistable signal that is opposed by an advective flow generated by an actomyosin stress gradient. Experimental observations on the behavior of the system when contractility is inhibited are in qualitative agreement with the predictions of the model. |
| first_indexed | 2024-12-23T19:14:16Z |
| format | Article |
| id | doaj.art-3e090f98abff4b48a5eb1481ba64b9e5 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-23T19:14:16Z |
| publishDate | 2017-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-3e090f98abff4b48a5eb1481ba64b9e52022-12-21T17:34:22ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582017-03-01133e100541110.1371/journal.pcbi.1005411Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions.Rashmi PriyaGuillermo A GomezSrikanth BudnarBipul R AcharyaBipul R AcharyaAndras CzirokAlpha S YapZoltan NeufeldMechanical coherence of cell layers is essential for epithelia to function as tissue barriers and to control active tissue dynamics during morphogenesis. RhoA signaling at adherens junctions plays a key role in this process by coupling cadherin-based cell-cell adhesion together with actomyosin contractility. Here we propose and analyze a mathematical model representing core interactions involved in the spatial localization of junctional RhoA signaling. We demonstrate how the interplay between biochemical signaling through positive feedback, combined with diffusion on the cell membrane and mechanical forces generated in the cortex, can determine the spatial distribution of RhoA signaling at cell-cell junctions. This dynamical mechanism relies on the balance between a propagating bistable signal that is opposed by an advective flow generated by an actomyosin stress gradient. Experimental observations on the behavior of the system when contractility is inhibited are in qualitative agreement with the predictions of the model.https://doi.org/10.1371/journal.pcbi.1005411 |
| spellingShingle | Rashmi Priya Guillermo A Gomez Srikanth Budnar Bipul R Acharya Bipul R Acharya Andras Czirok Alpha S Yap Zoltan Neufeld Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. PLoS Computational Biology |
| title | Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. |
| title_full | Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. |
| title_fullStr | Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. |
| title_full_unstemmed | Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. |
| title_short | Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. |
| title_sort | bistable front dynamics in a contractile medium travelling wave fronts and cortical advection define stable zones of rhoa signaling at epithelial adherens junctions |
| url | https://doi.org/10.1371/journal.pcbi.1005411 |
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