Pure T-cell mediated rejection following kidney transplant according to response to treatment.
The focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0256898 |
| _version_ | 1828955214645821440 |
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| author | Hyunwook Kwon Young Hoon Kim Youngmin Ko Seong Jun Lim Joo Hee Jung Chung Hee Baek Hyosang Kim Su-Kil Park Sung Shin Yong-Pil Cho |
| author_facet | Hyunwook Kwon Young Hoon Kim Youngmin Ko Seong Jun Lim Joo Hee Jung Chung Hee Baek Hyosang Kim Su-Kil Park Sung Shin Yong-Pil Cho |
| author_sort | Hyunwook Kwon |
| collection | DOAJ |
| description | The focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of pure TCMR on graft survival (GS) according to treatment response. We also performed molecular diagnosis using a molecular microscope diagnostic system on a separate group of 23 patients. A total of 63 patients were divided into non-responders (N = 22) and responders (N = 44). Non-response to rejection treatment was significantly associated with the following factors: glomerular filtration rate (GFR) at biopsy, ΔGFR, TCMR within one year, t score, and IF/TA score. We also found that non-responder vs. responder (OR = 3.31; P = 0.036) and lower GFR at biopsy (OR = 0.56; P = 0.026) were independent risk factors of graft failure. The responders had a significantly superior overall GS rate compared with the non-responders (P = 0.004). Molecular assessment showed a good correlation with histologic diagnosis in ABMR, but not in TCMR. Solitary TCMR was a significant risk factor of graft failure in patients who did not respond to rejection treatment. |
| first_indexed | 2024-12-14T07:46:41Z |
| format | Article |
| id | doaj.art-3e0b0f37327949bdb0d35e646e49d3af |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T07:46:41Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3e0b0f37327949bdb0d35e646e49d3af2022-12-21T23:10:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01169e025689810.1371/journal.pone.0256898Pure T-cell mediated rejection following kidney transplant according to response to treatment.Hyunwook KwonYoung Hoon KimYoungmin KoSeong Jun LimJoo Hee JungChung Hee BaekHyosang KimSu-Kil ParkSung ShinYong-Pil ChoThe focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of pure TCMR on graft survival (GS) according to treatment response. We also performed molecular diagnosis using a molecular microscope diagnostic system on a separate group of 23 patients. A total of 63 patients were divided into non-responders (N = 22) and responders (N = 44). Non-response to rejection treatment was significantly associated with the following factors: glomerular filtration rate (GFR) at biopsy, ΔGFR, TCMR within one year, t score, and IF/TA score. We also found that non-responder vs. responder (OR = 3.31; P = 0.036) and lower GFR at biopsy (OR = 0.56; P = 0.026) were independent risk factors of graft failure. The responders had a significantly superior overall GS rate compared with the non-responders (P = 0.004). Molecular assessment showed a good correlation with histologic diagnosis in ABMR, but not in TCMR. Solitary TCMR was a significant risk factor of graft failure in patients who did not respond to rejection treatment.https://doi.org/10.1371/journal.pone.0256898 |
| spellingShingle | Hyunwook Kwon Young Hoon Kim Youngmin Ko Seong Jun Lim Joo Hee Jung Chung Hee Baek Hyosang Kim Su-Kil Park Sung Shin Yong-Pil Cho Pure T-cell mediated rejection following kidney transplant according to response to treatment. PLoS ONE |
| title | Pure T-cell mediated rejection following kidney transplant according to response to treatment. |
| title_full | Pure T-cell mediated rejection following kidney transplant according to response to treatment. |
| title_fullStr | Pure T-cell mediated rejection following kidney transplant according to response to treatment. |
| title_full_unstemmed | Pure T-cell mediated rejection following kidney transplant according to response to treatment. |
| title_short | Pure T-cell mediated rejection following kidney transplant according to response to treatment. |
| title_sort | pure t cell mediated rejection following kidney transplant according to response to treatment |
| url | https://doi.org/10.1371/journal.pone.0256898 |
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