Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia

Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia

Background: Principal mechanisms of arrhythmia have been derived from ventricular but not atrial cardiomyocytes of animal models despite higher prevalence of atrial arrhythmia (e.g., atrial fibrillation). Due to significant ultrastructural and functional differences, a simple transfer of ventricular...

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Bibliographic Details
Main Authors: Nils Bögeholz, Paul Pauls, Dirk G. Dechering, Gerrit Frommeyer, Joshua I. Goldhaber, Christian Pott, Lars Eckardt, Frank U. Müller, Jan S. Schulte
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
afterdepolarizations
translational research
atrial cardiomyocytes
atrioventricular differences
atrial arrhythmia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00933/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00933/full

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