The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition
Epithelial-to-mesenchymal transition (EMT) is a process by which epithelial cells lose their basement membrane interaction and acquire a more migratory, mesenchymal phenotype. EMT has been implicated in cancer cell progression, as cells transform and increase motility and invasiveness, induce angiog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/9/8/105 |
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| author | Robert H. Blackwell Kimberly E. Foreman Gopal N. Gupta |
| author_facet | Robert H. Blackwell Kimberly E. Foreman Gopal N. Gupta |
| author_sort | Robert H. Blackwell |
| collection | DOAJ |
| description | Epithelial-to-mesenchymal transition (EMT) is a process by which epithelial cells lose their basement membrane interaction and acquire a more migratory, mesenchymal phenotype. EMT has been implicated in cancer cell progression, as cells transform and increase motility and invasiveness, induce angiogenesis, and metastasize. Exosomes are 30–100 nm membrane-bound vesicles that are formed and excreted by all cell types and released into the extracellular environment. Exosomal contents include DNA, mRNA, miRNA, as well as transmembrane- and membrane-bound proteins derived from their host cell contents. Exosomes are involved in intercellular signaling, both by membrane fusion to recipient cells with deposition of exosomal contents into the cytoplasm and by the binding of recipient cell membrane receptors. Recent work has implicated cancer-derived exosomes as an important mediator of intercellular signaling and EMT, with resultant transformation of cancer cells to a more aggressive phenotype, as well as the tropism of metastatic disease in specific cancer types with the establishment of the pre-metastatic niche. |
| first_indexed | 2024-03-12T05:43:20Z |
| format | Article |
| id | doaj.art-3e0bc733188b462f8731828a797ac99b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:43:20Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3e0bc733188b462f8731828a797ac99b2023-09-03T05:49:39ZengMDPI AGCancers2072-66942017-08-019810510.3390/cancers9080105cancers9080105The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal TransitionRobert H. Blackwell0Kimberly E. Foreman1Gopal N. Gupta2Department of Urology, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USACardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USADepartment of Urology, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USAEpithelial-to-mesenchymal transition (EMT) is a process by which epithelial cells lose their basement membrane interaction and acquire a more migratory, mesenchymal phenotype. EMT has been implicated in cancer cell progression, as cells transform and increase motility and invasiveness, induce angiogenesis, and metastasize. Exosomes are 30–100 nm membrane-bound vesicles that are formed and excreted by all cell types and released into the extracellular environment. Exosomal contents include DNA, mRNA, miRNA, as well as transmembrane- and membrane-bound proteins derived from their host cell contents. Exosomes are involved in intercellular signaling, both by membrane fusion to recipient cells with deposition of exosomal contents into the cytoplasm and by the binding of recipient cell membrane receptors. Recent work has implicated cancer-derived exosomes as an important mediator of intercellular signaling and EMT, with resultant transformation of cancer cells to a more aggressive phenotype, as well as the tropism of metastatic disease in specific cancer types with the establishment of the pre-metastatic niche.https://www.mdpi.com/2072-6694/9/8/105epithelial-mesenchymal transitionexosomesneoplasm metastasisneovascularizationpathologicneoplasm invasivenessintercellular signaling peptides and proteins |
| spellingShingle | Robert H. Blackwell Kimberly E. Foreman Gopal N. Gupta The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition Cancers epithelial-mesenchymal transition exosomes neoplasm metastasis neovascularization pathologic neoplasm invasiveness intercellular signaling peptides and proteins |
| title | The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition |
| title_full | The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition |
| title_fullStr | The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition |
| title_full_unstemmed | The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition |
| title_short | The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition |
| title_sort | role of cancer derived exosomes in tumorigenicity amp epithelial to mesenchymal transition |
| topic | epithelial-mesenchymal transition exosomes neoplasm metastasis neovascularization pathologic neoplasm invasiveness intercellular signaling peptides and proteins |
| url | https://www.mdpi.com/2072-6694/9/8/105 |
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