Design and Synthesis of Novel Phenylahistin Derivatives Based on Co-Crystal Structures as Potent Microtubule Inhibitors for Anti-Cancer Therapy

Design and Synthesis of Novel Phenylahistin Derivatives Based on Co-Crystal Structures as Potent Microtubule Inhibitors for Anti-Cancer Therapy

Phenylahistin is a naturally occurring marine product with a diketopiperazine structure that can bind to the colchicine site of microtubulin as a possible anticancer agent. To develop more potent microtubule inhibitors, novel phenylahistin derivatives were designed and synthesized based on the co-cr...

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Bibliographic Details
Main Authors: Zhongpeng Ding, Feifei Li, Lianghui Xie, Minqing Gu, Chunlei Li, Chang Liu, Chao Peng, Wenbao Li
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Marine Drugs
Subjects:
phenylahistin
allyl-imidazole-type
SAR
microtubule inhibitor
anticancer
Online Access:https://www.mdpi.com/1660-3397/20/12/752

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