Neurostimulation techniques to enhance sleep and improve cognition in aging
Sleep plays a critical role in the process of memory consolidation. In particular, during non-rapid eye movement (NREM) slow wave sleep, slow-oscillations, spindles, hippocampal sharp wave ripples, and their phase coupling are involved in the process of transferring and consolidating information rec...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-07-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996120301406 |
| _version_ | 1818620391358201856 |
|---|---|
| author | Daniela Grimaldi Nelly A. Papalambros Phyllis C. Zee Roneil G. Malkani |
| author_facet | Daniela Grimaldi Nelly A. Papalambros Phyllis C. Zee Roneil G. Malkani |
| author_sort | Daniela Grimaldi |
| collection | DOAJ |
| description | Sleep plays a critical role in the process of memory consolidation. In particular, during non-rapid eye movement (NREM) slow wave sleep, slow-oscillations, spindles, hippocampal sharp wave ripples, and their phase coupling are involved in the process of transferring and consolidating information recently encoded and temporarily stored in the hippocampus into long-term memory stored in the neocortex. There is evidence that aging and neurodegenerative conditions, in particular Alzheimer's disease, are associated with changes to this transient grouping of NREM oscillations. Therefore, methods to enhance sleep, particularly slow wave sleep, have the potential to improve cognitive performance. Transcranial electrical and magnetic stimulation have been shown useful to enhance sleep slow-waves and sleep-dependent memory consolidation, however there is need for more information regarding proper protocols of application and applicability and efficacy in patients with neurodegenerative conditions. Acoustic stimulation during sleep has been proven particularly effective in enhancing sleep slow-waves and spindles with associated improvement in overnight memory consolidation. More importantly, preliminary data indicate that similar results can be achieved in healthy older adults and those with amnestic mild cognitive impairment. Studies are needed to optimize the modalities of acoustic stimulation during sleep, which may vary based on age group or clinical disorder. Overall, non-invasive techniques of neurostimulation may represent a valid approach to mitigate cognitive decline associated with aging and neurodegeneration. Furthermore, they offer the unique opportunity to improve our understanding of the physiology behind sleep-dependent memory consolidation. |
| first_indexed | 2024-12-16T17:52:38Z |
| format | Article |
| id | doaj.art-3e100a7579ad44fc904587025cb78941 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-16T17:52:38Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-3e100a7579ad44fc904587025cb789412022-12-21T22:22:15ZengElsevierNeurobiology of Disease1095-953X2020-07-01141104865Neurostimulation techniques to enhance sleep and improve cognition in agingDaniela Grimaldi0Nelly A. Papalambros1Phyllis C. Zee2Roneil G. Malkani3Department of Neurology, Northwestern University, Feinberg School of Medicine, 710 N. Lake Shore Drive, 60611 Chicago, IL, USADepartment of Neurology, Northwestern University, Feinberg School of Medicine, 710 N. Lake Shore Drive, 60611 Chicago, IL, USADepartment of Neurology, Northwestern University, Feinberg School of Medicine, 710 N. Lake Shore Drive, 60611 Chicago, IL, USACorresponding author at: Center for Circadian and Sleep Medicine, Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Suite 520, Chicago, IL 60611, USA.; Department of Neurology, Northwestern University, Feinberg School of Medicine, 710 N. Lake Shore Drive, 60611 Chicago, IL, USASleep plays a critical role in the process of memory consolidation. In particular, during non-rapid eye movement (NREM) slow wave sleep, slow-oscillations, spindles, hippocampal sharp wave ripples, and their phase coupling are involved in the process of transferring and consolidating information recently encoded and temporarily stored in the hippocampus into long-term memory stored in the neocortex. There is evidence that aging and neurodegenerative conditions, in particular Alzheimer's disease, are associated with changes to this transient grouping of NREM oscillations. Therefore, methods to enhance sleep, particularly slow wave sleep, have the potential to improve cognitive performance. Transcranial electrical and magnetic stimulation have been shown useful to enhance sleep slow-waves and sleep-dependent memory consolidation, however there is need for more information regarding proper protocols of application and applicability and efficacy in patients with neurodegenerative conditions. Acoustic stimulation during sleep has been proven particularly effective in enhancing sleep slow-waves and spindles with associated improvement in overnight memory consolidation. More importantly, preliminary data indicate that similar results can be achieved in healthy older adults and those with amnestic mild cognitive impairment. Studies are needed to optimize the modalities of acoustic stimulation during sleep, which may vary based on age group or clinical disorder. Overall, non-invasive techniques of neurostimulation may represent a valid approach to mitigate cognitive decline associated with aging and neurodegeneration. Furthermore, they offer the unique opportunity to improve our understanding of the physiology behind sleep-dependent memory consolidation.http://www.sciencedirect.com/science/article/pii/S0969996120301406SleepAgingNeurodegenerationAmnestic mild cognitive impairmentMemory consolidationSlow wave sleep |
| spellingShingle | Daniela Grimaldi Nelly A. Papalambros Phyllis C. Zee Roneil G. Malkani Neurostimulation techniques to enhance sleep and improve cognition in aging Neurobiology of Disease Sleep Aging Neurodegeneration Amnestic mild cognitive impairment Memory consolidation Slow wave sleep |
| title | Neurostimulation techniques to enhance sleep and improve cognition in aging |
| title_full | Neurostimulation techniques to enhance sleep and improve cognition in aging |
| title_fullStr | Neurostimulation techniques to enhance sleep and improve cognition in aging |
| title_full_unstemmed | Neurostimulation techniques to enhance sleep and improve cognition in aging |
| title_short | Neurostimulation techniques to enhance sleep and improve cognition in aging |
| title_sort | neurostimulation techniques to enhance sleep and improve cognition in aging |
| topic | Sleep Aging Neurodegeneration Amnestic mild cognitive impairment Memory consolidation Slow wave sleep |
| url | http://www.sciencedirect.com/science/article/pii/S0969996120301406 |
| work_keys_str_mv | AT danielagrimaldi neurostimulationtechniquestoenhancesleepandimprovecognitioninaging AT nellyapapalambros neurostimulationtechniquestoenhancesleepandimprovecognitioninaging AT phyllisczee neurostimulationtechniquestoenhancesleepandimprovecognitioninaging AT roneilgmalkani neurostimulationtechniquestoenhancesleepandimprovecognitioninaging |