Loss of STAT2 may be dangerous in a world filled with viruses
Type I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere with viral replication. While type II IFN (IFN-γ) largely protects against intracellular bacteria and protozoa, type I IFNs largely protect from vira...
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2023-06-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI170886 |
| _version_ | 1797634422417129472 |
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| author | Michael B. Jordan |
| author_facet | Michael B. Jordan |
| author_sort | Michael B. Jordan |
| collection | DOAJ |
| description | Type I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere with viral replication. While type II IFN (IFN-γ) largely protects against intracellular bacteria and protozoa, type I IFNs largely protect from viral infections. Inborn errors of immunity in humans have demonstrated this point and its clinical relevance with increasing clarity. In this issue of the JCI, Bucciol, Moens, et al. report the largest series of patients to date with deficiency of STAT2, an important protein for type I IFN signaling. Individuals with STAT2 loss demonstrated a clinical phenotype of viral susceptibility and inflammatory complications, many of which remain poorly understood. These findings further illustrate the very specific and critical role that type I IFNs play in host defense against viruses. |
| first_indexed | 2024-03-11T12:08:38Z |
| format | Article |
| id | doaj.art-3e1029cdb09b448fa6f5750e3251f9da |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:08:38Z |
| publishDate | 2023-06-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-3e1029cdb09b448fa6f5750e3251f9da2023-11-07T16:20:29ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-06-0113312Loss of STAT2 may be dangerous in a world filled with virusesMichael B. JordanType I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere with viral replication. While type II IFN (IFN-γ) largely protects against intracellular bacteria and protozoa, type I IFNs largely protect from viral infections. Inborn errors of immunity in humans have demonstrated this point and its clinical relevance with increasing clarity. In this issue of the JCI, Bucciol, Moens, et al. report the largest series of patients to date with deficiency of STAT2, an important protein for type I IFN signaling. Individuals with STAT2 loss demonstrated a clinical phenotype of viral susceptibility and inflammatory complications, many of which remain poorly understood. These findings further illustrate the very specific and critical role that type I IFNs play in host defense against viruses.https://doi.org/10.1172/JCI170886 |
| spellingShingle | Michael B. Jordan Loss of STAT2 may be dangerous in a world filled with viruses The Journal of Clinical Investigation |
| title | Loss of STAT2 may be dangerous in a world filled with viruses |
| title_full | Loss of STAT2 may be dangerous in a world filled with viruses |
| title_fullStr | Loss of STAT2 may be dangerous in a world filled with viruses |
| title_full_unstemmed | Loss of STAT2 may be dangerous in a world filled with viruses |
| title_short | Loss of STAT2 may be dangerous in a world filled with viruses |
| title_sort | loss of stat2 may be dangerous in a world filled with viruses |
| url | https://doi.org/10.1172/JCI170886 |
| work_keys_str_mv | AT michaelbjordan lossofstat2maybedangerousinaworldfilledwithviruses |