Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection
Improving early detection of lung cancer is critical to improving lung cancer survival. Studies have shown that computerized tomography (CT) screening can reduce mortality from lung cancer, but this involves risks of radiation exposure and can identify non-cancer lung nodules that lead to unnecessar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/8/7/61 |
| _version_ | 1797720821313044480 |
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| author | Vasudha Murlidhar Nithya Ramnath Sunitha Nagrath Rishindra M. Reddy |
| author_facet | Vasudha Murlidhar Nithya Ramnath Sunitha Nagrath Rishindra M. Reddy |
| author_sort | Vasudha Murlidhar |
| collection | DOAJ |
| description | Improving early detection of lung cancer is critical to improving lung cancer survival. Studies have shown that computerized tomography (CT) screening can reduce mortality from lung cancer, but this involves risks of radiation exposure and can identify non-cancer lung nodules that lead to unnecessary interventions for some. There is a critical need to develop alternative, less invasive methods to identify patients who have early-stage lung cancer. The detection of circulating tumor cells (CTCs) are a promising area of research, but current technology is limited by a low yield of CTCs. Alternate studies are investigating circulating nucleic acids and proteins as possible tumor markers. It is critical to develop innovative methods for early lung cancer detection that may include CTCs or other markers that are low-risk and low-cost, yet specific and sensitive, to facilitate improved survival by diagnosing the disease when it is surgically curable. |
| first_indexed | 2024-03-12T09:25:03Z |
| format | Article |
| id | doaj.art-3e10a556bbc947d1aa24438a07908d36 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:25:03Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3e10a556bbc947d1aa24438a07908d362023-09-02T14:15:06ZengMDPI AGCancers2072-66942016-06-01876110.3390/cancers8070061cancers8070061Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer DetectionVasudha Murlidhar0Nithya Ramnath1Sunitha Nagrath2Rishindra M. Reddy3Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USADivision of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USADepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USASection of Thoracic Surgery, Department of Surgery, University of Michigan, Taubman Center 2120, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USAImproving early detection of lung cancer is critical to improving lung cancer survival. Studies have shown that computerized tomography (CT) screening can reduce mortality from lung cancer, but this involves risks of radiation exposure and can identify non-cancer lung nodules that lead to unnecessary interventions for some. There is a critical need to develop alternative, less invasive methods to identify patients who have early-stage lung cancer. The detection of circulating tumor cells (CTCs) are a promising area of research, but current technology is limited by a low yield of CTCs. Alternate studies are investigating circulating nucleic acids and proteins as possible tumor markers. It is critical to develop innovative methods for early lung cancer detection that may include CTCs or other markers that are low-risk and low-cost, yet specific and sensitive, to facilitate improved survival by diagnosing the disease when it is surgically curable.http://www.mdpi.com/2072-6694/8/7/61biomarkerscirculating tumor cellsmicroRNAlung cancerproteomics |
| spellingShingle | Vasudha Murlidhar Nithya Ramnath Sunitha Nagrath Rishindra M. Reddy Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection Cancers biomarkers circulating tumor cells microRNA lung cancer proteomics |
| title | Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection |
| title_full | Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection |
| title_fullStr | Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection |
| title_full_unstemmed | Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection |
| title_short | Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection |
| title_sort | optimizing the detection of circulating markers to aid in early lung cancer detection |
| topic | biomarkers circulating tumor cells microRNA lung cancer proteomics |
| url | http://www.mdpi.com/2072-6694/8/7/61 |
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