Atopy in chronic urticaria: an important yet overlooked issue
Chronic urticaria (CU) is one of the most common dermatological diseases and has a significant impact on the quality of life of patients. However, the pathogenesis of this disease remains unclear. Autoimmunity in chronic spontaneous urticaria (CSU) has received considerable attention and has been st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1279976/full |
| _version_ | 1827357373689233408 |
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| author | Qiquan Chen Xianjie Yang Xianjie Yang Bing Ni Zhiqiang Song |
| author_facet | Qiquan Chen Xianjie Yang Xianjie Yang Bing Ni Zhiqiang Song |
| author_sort | Qiquan Chen |
| collection | DOAJ |
| description | Chronic urticaria (CU) is one of the most common dermatological diseases and has a significant impact on the quality of life of patients. However, the pathogenesis of this disease remains unclear. Autoimmunity in chronic spontaneous urticaria (CSU) has received considerable attention and has been studied previously. Atopy is an important characteristic of CU; however, it has not been fully recognized. Atopy predisposes individuals to immune responses to allergens, leading to type 2 inflammation and immunoglobulin E (IgE) overproduction. Compared with healthy individuals, patients with CU have a higher proportion of atopy, and an atopic background is correlated with the clinical characteristics of CU. The total IgE levels in patients with CU is significantly higher than those in healthy individuals. Although its level is not higher than that in classic allergic diseases, it is closely related to CU. Exogenous allergens, auto-allergens, and specific IgEs, which are closely related to atopy, have been reported, and their roles in CU pathogenesis are also being studied. Local and systemic atopic inflammation is present in patients with CU. This review summarizes the current knowledge regarding atopy and CU, speculating that there are CU subtypes, such as atopic CSU or atopic chronic inducible urticaria (CIndU) and that atopy may be involved in the pathogenesis of CU. These findings provide a new perspective for a comprehensive understanding of the clinical features of CU and further research regarding its pathogenesis. |
| first_indexed | 2024-03-08T05:31:52Z |
| format | Article |
| id | doaj.art-3e10d81e6851440dacb0cbd8837fa241 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T05:31:52Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3e10d81e6851440dacb0cbd8837fa2412024-02-06T04:42:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12799761279976Atopy in chronic urticaria: an important yet overlooked issueQiquan Chen0Xianjie Yang1Xianjie Yang2Bing Ni3Zhiqiang Song4Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, ChinaDepartment of Dermatology, Southwest Hospital, Army Medical University, Chongqing, ChinaSchool of Medicine, Chongqing University, Chongqing, ChinaDepartment of Pathophysiology, Army Medical University, Chongqing, ChinaDepartment of Dermatology, Southwest Hospital, Army Medical University, Chongqing, ChinaChronic urticaria (CU) is one of the most common dermatological diseases and has a significant impact on the quality of life of patients. However, the pathogenesis of this disease remains unclear. Autoimmunity in chronic spontaneous urticaria (CSU) has received considerable attention and has been studied previously. Atopy is an important characteristic of CU; however, it has not been fully recognized. Atopy predisposes individuals to immune responses to allergens, leading to type 2 inflammation and immunoglobulin E (IgE) overproduction. Compared with healthy individuals, patients with CU have a higher proportion of atopy, and an atopic background is correlated with the clinical characteristics of CU. The total IgE levels in patients with CU is significantly higher than those in healthy individuals. Although its level is not higher than that in classic allergic diseases, it is closely related to CU. Exogenous allergens, auto-allergens, and specific IgEs, which are closely related to atopy, have been reported, and their roles in CU pathogenesis are also being studied. Local and systemic atopic inflammation is present in patients with CU. This review summarizes the current knowledge regarding atopy and CU, speculating that there are CU subtypes, such as atopic CSU or atopic chronic inducible urticaria (CIndU) and that atopy may be involved in the pathogenesis of CU. These findings provide a new perspective for a comprehensive understanding of the clinical features of CU and further research regarding its pathogenesis.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1279976/fullchronic urticariachronic spontaneous urticariachronic inducible urticariaatopyIgEmast cell |
| spellingShingle | Qiquan Chen Xianjie Yang Xianjie Yang Bing Ni Zhiqiang Song Atopy in chronic urticaria: an important yet overlooked issue Frontiers in Immunology chronic urticaria chronic spontaneous urticaria chronic inducible urticaria atopy IgE mast cell |
| title | Atopy in chronic urticaria: an important yet overlooked issue |
| title_full | Atopy in chronic urticaria: an important yet overlooked issue |
| title_fullStr | Atopy in chronic urticaria: an important yet overlooked issue |
| title_full_unstemmed | Atopy in chronic urticaria: an important yet overlooked issue |
| title_short | Atopy in chronic urticaria: an important yet overlooked issue |
| title_sort | atopy in chronic urticaria an important yet overlooked issue |
| topic | chronic urticaria chronic spontaneous urticaria chronic inducible urticaria atopy IgE mast cell |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1279976/full |
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