Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection
BackgroundThe clinical outcomes for brain tumor resection have been shown to be significantly improved with increased extent of resection. To achieve this, neurosurgeons employ different intra-operative tools to improve the extent of resection of brain tumors, including ultrasound, CT, and MRI. Youn...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.619286/full |
| _version_ | 1818329980600320000 |
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| author | Huan Wee Chan Huan Wee Chan Christopher Uff Aabir Chakraborty Neil Dorward Jeffrey Colin Bamber |
| author_facet | Huan Wee Chan Huan Wee Chan Christopher Uff Aabir Chakraborty Neil Dorward Jeffrey Colin Bamber |
| author_sort | Huan Wee Chan |
| collection | DOAJ |
| description | BackgroundThe clinical outcomes for brain tumor resection have been shown to be significantly improved with increased extent of resection. To achieve this, neurosurgeons employ different intra-operative tools to improve the extent of resection of brain tumors, including ultrasound, CT, and MRI. Young’s modulus (YM) of brain tumors have been shown to be different from normal brain but the accuracy of SWE in assisting brain tumor resection has not been reported.AimsTo determine the accuracy of SWE in detecting brain tumor residual using post-operative MRI scan as “gold standard”.MethodsThirty-four patients (aged 1–62 years, M:F = 15:20) with brain tumors were recruited into the study. The intraoperative SWE scans were performed using Aixplorer® (SuperSonic Imagine, France) using a sector transducer (SE12-3) and a linear transducer (SL15-4) with a bandwidth of 3 to 12 MHz and 4 to 15 MHz, respectively, using the SWE mode. The scans were performed prior, during and after brain tumor resection. The presence of residual tumor was determined by the surgeon, ultrasound (US) B-mode and SWE. This was compared with the presence of residual tumor on post-operative MRI scan.ResultsThe YM of the brain tumors correlated significantly with surgeons’ findings (ρ = 0.845, p < 0.001). The sensitivities of residual tumor detection by the surgeon, US B-mode and SWE were 36%, 73%, and 94%, respectively, while their specificities were 100%, 63%, and 77%, respectively. There was no significant difference between detection of residual tumor by SWE, US B-mode, and MRI. SWE and MRI were significantly better than the surgeon’s detection of residual tumor (p = 0.001 and p < 0.001, respectively).ConclusionsSWE had a higher sensitivity in detecting residual tumor than the surgeons (94% vs. 36%). However, the surgeons had a higher specificity than SWE (100% vs. 77%). Therefore, using SWE in combination with surgeon’s opinion may optimize the detection of residual tumor, and hence improve the extent of brain tumor resection. |
| first_indexed | 2024-12-13T12:56:41Z |
| format | Article |
| id | doaj.art-3e132728443e4e80a1c37398956c2274 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T12:56:41Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3e132728443e4e80a1c37398956c22742022-12-21T23:45:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.619286619286Clinical Application of Shear Wave Elastography for Assisting Brain Tumor ResectionHuan Wee Chan0Huan Wee Chan1Christopher Uff2Aabir Chakraborty3Neil Dorward4Jeffrey Colin Bamber5Joint Department of Physics, Institute of Cancer Research and the Royal Marsden Hospital, Sutton, United KingdomNeurosurgery Department, Southampton General Hospital, Southampton, United KingdomNeurosurgery Department, Royal London Hospital, London, United KingdomNeurosurgery Department, Southampton General Hospital, Southampton, United KingdomNeurosurgery Department, The National Hospital for Neurology and Neurosurgery, London, United KingdomJoint Department of Physics, Institute of Cancer Research and the Royal Marsden Hospital, Sutton, United KingdomBackgroundThe clinical outcomes for brain tumor resection have been shown to be significantly improved with increased extent of resection. To achieve this, neurosurgeons employ different intra-operative tools to improve the extent of resection of brain tumors, including ultrasound, CT, and MRI. Young’s modulus (YM) of brain tumors have been shown to be different from normal brain but the accuracy of SWE in assisting brain tumor resection has not been reported.AimsTo determine the accuracy of SWE in detecting brain tumor residual using post-operative MRI scan as “gold standard”.MethodsThirty-four patients (aged 1–62 years, M:F = 15:20) with brain tumors were recruited into the study. The intraoperative SWE scans were performed using Aixplorer® (SuperSonic Imagine, France) using a sector transducer (SE12-3) and a linear transducer (SL15-4) with a bandwidth of 3 to 12 MHz and 4 to 15 MHz, respectively, using the SWE mode. The scans were performed prior, during and after brain tumor resection. The presence of residual tumor was determined by the surgeon, ultrasound (US) B-mode and SWE. This was compared with the presence of residual tumor on post-operative MRI scan.ResultsThe YM of the brain tumors correlated significantly with surgeons’ findings (ρ = 0.845, p < 0.001). The sensitivities of residual tumor detection by the surgeon, US B-mode and SWE were 36%, 73%, and 94%, respectively, while their specificities were 100%, 63%, and 77%, respectively. There was no significant difference between detection of residual tumor by SWE, US B-mode, and MRI. SWE and MRI were significantly better than the surgeon’s detection of residual tumor (p = 0.001 and p < 0.001, respectively).ConclusionsSWE had a higher sensitivity in detecting residual tumor than the surgeons (94% vs. 36%). However, the surgeons had a higher specificity than SWE (100% vs. 77%). Therefore, using SWE in combination with surgeon’s opinion may optimize the detection of residual tumor, and hence improve the extent of brain tumor resection.https://www.frontiersin.org/articles/10.3389/fonc.2021.619286/fullbrain tumordetecting brain tumor residualelastographyshear waveintraoperative ultrasound |
| spellingShingle | Huan Wee Chan Huan Wee Chan Christopher Uff Aabir Chakraborty Neil Dorward Jeffrey Colin Bamber Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection Frontiers in Oncology brain tumor detecting brain tumor residual elastography shear wave intraoperative ultrasound |
| title | Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection |
| title_full | Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection |
| title_fullStr | Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection |
| title_full_unstemmed | Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection |
| title_short | Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection |
| title_sort | clinical application of shear wave elastography for assisting brain tumor resection |
| topic | brain tumor detecting brain tumor residual elastography shear wave intraoperative ultrasound |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.619286/full |
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