The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection
Objectives: The platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been studied widely in cancer diseases. However, their correlation with hepatitis C virus (HCV) infection is unknown. The aim of this study was to investigate the correlation of PLR and NLR with disease...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971216300042 |
| _version_ | 1818450472167538688 |
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| author | Xianchun Meng Gaohui Wei Qian Chang Ruoyu Peng Guang Shi Peiguo Zheng Fucheng He Wanhai Wang Liang Ming |
| author_facet | Xianchun Meng Gaohui Wei Qian Chang Ruoyu Peng Guang Shi Peiguo Zheng Fucheng He Wanhai Wang Liang Ming |
| author_sort | Xianchun Meng |
| collection | DOAJ |
| description | Objectives: The platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been studied widely in cancer diseases. However, their correlation with hepatitis C virus (HCV) infection is unknown. The aim of this study was to investigate the correlation of PLR and NLR with disease severity in patients with HCV-related liver disease and the virological response in chronic hepatitis C (CHC) patients.
Methods: The clinical data of 120 HCV-infected patients and 40 healthy controls were analyzed. The clinical data of 24 CHC patients who had been followed up regularly were collected for the following time points: before treatment (week 0) and weeks 4, 48, and 72 during treatment. These data were also analyzed. All data were collected from the database of the hospital patient electronic medical record system.
Results: The HCV-related cirrhosis group and HCV-related hepatocellular carcinoma group were found to have lower PLRs (61 ± 31 and 51 ± 23) than the healthy controls (115 ± 23). The PLR of the HCV cleared group (154 ± 85) was significantly higher than that of the HCV untreated group and HCV uncleared group (90 ± 28 and 88 ± 40, respectively). Receiver operating characteristics curve analysis for the PLR showed an area under the curve of 0.772 (95% confidence interval 0.674–0.869, p < 0.000); for NLR, the area under the curve was 0.612 (95% confidence interval 0.495–0.730, p = 0.063). Furthermore, an increasing PLR in CHC patients indicated a good virological response, and a stable PLR or a downward trend in PLR could predict no rapid virological response being achieved by week 4, and even no sustained virological response by week 72.
Conclusions: The PLR is closely related to disease severity in patients with HCV-related liver disease and to the virological response in CHC patients. Dynamic continuous monitoring of the PLR will contribute to disease surveillance, with an increasing tendency predicting a good virological response. |
| first_indexed | 2024-12-14T20:51:50Z |
| format | Article |
| id | doaj.art-3e14d140d8604ec4851a3863989ca06c |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-14T20:51:50Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-3e14d140d8604ec4851a3863989ca06c2022-12-21T22:47:48ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112016-04-0145C727710.1016/j.ijid.2016.02.025The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infectionXianchun Meng0Gaohui Wei1Qian Chang2Ruoyu Peng3Guang Shi4Peiguo Zheng5Fucheng He6Wanhai Wang7Liang Ming8Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaClinical Laboratory, First Affiliated Hospital of Zhengzhou University, Jianshe Road 1st, Zhengzhou, Henan 450052, ChinaObjectives: The platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been studied widely in cancer diseases. However, their correlation with hepatitis C virus (HCV) infection is unknown. The aim of this study was to investigate the correlation of PLR and NLR with disease severity in patients with HCV-related liver disease and the virological response in chronic hepatitis C (CHC) patients. Methods: The clinical data of 120 HCV-infected patients and 40 healthy controls were analyzed. The clinical data of 24 CHC patients who had been followed up regularly were collected for the following time points: before treatment (week 0) and weeks 4, 48, and 72 during treatment. These data were also analyzed. All data were collected from the database of the hospital patient electronic medical record system. Results: The HCV-related cirrhosis group and HCV-related hepatocellular carcinoma group were found to have lower PLRs (61 ± 31 and 51 ± 23) than the healthy controls (115 ± 23). The PLR of the HCV cleared group (154 ± 85) was significantly higher than that of the HCV untreated group and HCV uncleared group (90 ± 28 and 88 ± 40, respectively). Receiver operating characteristics curve analysis for the PLR showed an area under the curve of 0.772 (95% confidence interval 0.674–0.869, p < 0.000); for NLR, the area under the curve was 0.612 (95% confidence interval 0.495–0.730, p = 0.063). Furthermore, an increasing PLR in CHC patients indicated a good virological response, and a stable PLR or a downward trend in PLR could predict no rapid virological response being achieved by week 4, and even no sustained virological response by week 72. Conclusions: The PLR is closely related to disease severity in patients with HCV-related liver disease and to the virological response in CHC patients. Dynamic continuous monitoring of the PLR will contribute to disease surveillance, with an increasing tendency predicting a good virological response.http://www.sciencedirect.com/science/article/pii/S1201971216300042Platelet-to-lymphocyte ratioNeutrophil-to-lymphocyte ratioSeverityVirological responseHCV |
| spellingShingle | Xianchun Meng Gaohui Wei Qian Chang Ruoyu Peng Guang Shi Peiguo Zheng Fucheng He Wanhai Wang Liang Ming The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection International Journal of Infectious Diseases Platelet-to-lymphocyte ratio Neutrophil-to-lymphocyte ratio Severity Virological response HCV |
| title | The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection |
| title_full | The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection |
| title_fullStr | The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection |
| title_full_unstemmed | The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection |
| title_short | The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection |
| title_sort | platelet to lymphocyte ratio superior to the neutrophil to lymphocyte ratio correlates with hepatitis c virus infection |
| topic | Platelet-to-lymphocyte ratio Neutrophil-to-lymphocyte ratio Severity Virological response HCV |
| url | http://www.sciencedirect.com/science/article/pii/S1201971216300042 |
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