Bacterial cell cycle control by citrate synthase independent of enzymatic activity

Bacterial cell cycle control by citrate synthase independent of enzymatic activity

Proliferating cells must coordinate central metabolism with the cell cycle. How central energy metabolism regulates bacterial cell cycle functions is not well understood. Our forward genetic selection unearthed the Krebs cycle enzyme citrate synthase (CitA) as a checkpoint regulator controlling the...

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Bibliographic Details
Main Authors: Matthieu Bergé, Julian Pezzatti, Víctor González-Ruiz, Laurence Degeorges, Geneviève Mottet-Osman, Serge Rudaz, Patrick H Viollier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
Caulobacter crescentus
TCA cycle
citrate synthase
cell development
(p)ppGpp
moonlighting enzyme
Online Access:https://elifesciences.org/articles/52272

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