LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

Abstract Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regul...

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Bibliographic Details
Main Authors: Lukas Leiendecker, Pauline S Jung, Izabela Krecioch, Tobias Neumann, Alexander Schleiffer, Karl Mechtler, Thomas Wiesner, Anna C Obenauf
Format: Article
Language:English
Published: Springer Nature 2020-11-01
Series:EMBO Molecular Medicine
Subjects:
epigenetics
HMG20B
LSD1
merkel cell carcinoma
targeted therapy
Online Access:https://doi.org/10.15252/emmm.202012525

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