Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.723840/full |
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| author | Ruihua Dong Ruihua Dong Haijiang Lin Haijiang Lin Xiaoxiao Chen Ruizi Shi Shiying Yuan Jing Li Bowen Zhu Xiaohui Xu Weiwei Shen Keran Wang Xiao-Ou Shu Ding Ding Na He Na He |
| author_facet | Ruihua Dong Ruihua Dong Haijiang Lin Haijiang Lin Xiaoxiao Chen Ruizi Shi Shiying Yuan Jing Li Bowen Zhu Xiaohui Xu Weiwei Shen Keran Wang Xiao-Ou Shu Ding Ding Na He Na He |
| author_sort | Ruihua Dong |
| collection | DOAJ |
| description | Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two groups—those with NCI and those without—using the global deficit score (GDS). Fecal samples were collected from the participants for 16S rRNA gene sequencing and untargeted metabolomics. The plasma level of 25 hydroxy-vitamin D (25(OH)D) was also evaluated. Although α-diversity and β-diversity were comparable, the HIV patients with NCI were significantly different from those without NCI in terms of abundance of several gut microbiota. The decreased abundance of butyrate-producing bacteria (BPB) and increased abundance of Klebsiella were related with NCI and carotid intima-media thickness (CIMT). Significant differences in fecal metabolites were also found between individuals with versus without NCI, including increased bile acids and bioactive lipids, decreased vitamin D, terpenoids, and resolvin D1 in the NCI group. Furthermore, the perturbed metabolic profile was closely related to BPB and Klebsiella. In addition, a low level of vitamin D was associated with NCI and CIMT. Both fecal and plasma vitamin D were positively correlated with BPB. Our results show that BPB and Klebsiella and the associated metabolites are associated with NCI in people with HIV. In addition, vitamin D, both in feces and blood, was associated with NCI and BPB, suggesting a protective effect of vitamin D on NCI. |
| first_indexed | 2024-12-19T00:25:32Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-19T00:25:32Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-3e18820c88ed4f7f87b9baa913910bd92022-12-21T20:45:17ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-10-011110.3389/fcimb.2021.723840723840Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected PopulationRuihua Dong0Ruihua Dong1Haijiang Lin2Haijiang Lin3Xiaoxiao Chen4Ruizi Shi5Shiying Yuan6Jing Li7Bowen Zhu8Xiaohui Xu9Weiwei Shen10Keran Wang11Xiao-Ou Shu12Ding Ding13Na He14Na He15Department of Nutrition and Food Hygiene, School of Public Health, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, Taizhou City Center for Disease Control and Prevention, Taizhou, ChinaDepartment of Epidemiology, Taizhou City Center for Disease Control and Prevention, Taizhou, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Epidemiology, Taizhou City Center for Disease Control and Prevention, Taizhou, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, United StatesInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai, ChinaGut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two groups—those with NCI and those without—using the global deficit score (GDS). Fecal samples were collected from the participants for 16S rRNA gene sequencing and untargeted metabolomics. The plasma level of 25 hydroxy-vitamin D (25(OH)D) was also evaluated. Although α-diversity and β-diversity were comparable, the HIV patients with NCI were significantly different from those without NCI in terms of abundance of several gut microbiota. The decreased abundance of butyrate-producing bacteria (BPB) and increased abundance of Klebsiella were related with NCI and carotid intima-media thickness (CIMT). Significant differences in fecal metabolites were also found between individuals with versus without NCI, including increased bile acids and bioactive lipids, decreased vitamin D, terpenoids, and resolvin D1 in the NCI group. Furthermore, the perturbed metabolic profile was closely related to BPB and Klebsiella. In addition, a low level of vitamin D was associated with NCI and CIMT. Both fecal and plasma vitamin D were positively correlated with BPB. Our results show that BPB and Klebsiella and the associated metabolites are associated with NCI in people with HIV. In addition, vitamin D, both in feces and blood, was associated with NCI and BPB, suggesting a protective effect of vitamin D on NCI.https://www.frontiersin.org/articles/10.3389/fcimb.2021.723840/fullHIVneurocognitive impairment (NCI)gut microbiotabutyrate-producing bacteriametabolomicsvitamin D |
| spellingShingle | Ruihua Dong Ruihua Dong Haijiang Lin Haijiang Lin Xiaoxiao Chen Ruizi Shi Shiying Yuan Jing Li Bowen Zhu Xiaohui Xu Weiwei Shen Keran Wang Xiao-Ou Shu Ding Ding Na He Na He Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population Frontiers in Cellular and Infection Microbiology HIV neurocognitive impairment (NCI) gut microbiota butyrate-producing bacteria metabolomics vitamin D |
| title | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
| title_full | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
| title_fullStr | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
| title_full_unstemmed | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
| title_short | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
| title_sort | gut microbiota and fecal metabolites associated with neurocognitive impairment in hiv infected population |
| topic | HIV neurocognitive impairment (NCI) gut microbiota butyrate-producing bacteria metabolomics vitamin D |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.723840/full |
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