Circular RNAs: emerging cancer biomarkers and targets
Abstract CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13046-017-0624-z |
| _version_ | 1811284231222984704 |
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| author | Yu Zhang Wei Liang Peng Zhang Jingyan Chen Hui Qian Xu Zhang Wenrong Xu |
| author_facet | Yu Zhang Wei Liang Peng Zhang Jingyan Chen Hui Qian Xu Zhang Wenrong Xu |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Abstract CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translational levels. An increasing number of studies have shown that circRNAs play important roles in the development and progression of diseases including cancer. In particular, circRNAs have shown great potential in cancer diagnosis, prognosis, and therapy. In this review, we provide an overview of the biogenesis and characteristics of circRNAs, succinctly describe their functions, and comprehensively discuss about the recent advances in the roles of circRNAs in cancer with an emphasis on their clinical values. |
| first_indexed | 2024-04-13T02:25:33Z |
| format | Article |
| id | doaj.art-3e196e14d4d4483bae6606ae6af3f7a2 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-13T02:25:33Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-3e196e14d4d4483bae6606ae6af3f7a22022-12-22T03:06:48ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662017-11-0136111310.1186/s13046-017-0624-zCircular RNAs: emerging cancer biomarkers and targetsYu Zhang0Wei Liang1Peng Zhang2Jingyan Chen3Hui Qian4Xu Zhang5Wenrong Xu6Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu UniversityJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu UniversityJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu UniversityJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu UniversityJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu UniversityJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu UniversityJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu UniversityAbstract CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translational levels. An increasing number of studies have shown that circRNAs play important roles in the development and progression of diseases including cancer. In particular, circRNAs have shown great potential in cancer diagnosis, prognosis, and therapy. In this review, we provide an overview of the biogenesis and characteristics of circRNAs, succinctly describe their functions, and comprehensively discuss about the recent advances in the roles of circRNAs in cancer with an emphasis on their clinical values.http://link.springer.com/article/10.1186/s13046-017-0624-zCircRNACancerceRNABiomarkerTarget |
| spellingShingle | Yu Zhang Wei Liang Peng Zhang Jingyan Chen Hui Qian Xu Zhang Wenrong Xu Circular RNAs: emerging cancer biomarkers and targets Journal of Experimental & Clinical Cancer Research CircRNA Cancer ceRNA Biomarker Target |
| title | Circular RNAs: emerging cancer biomarkers and targets |
| title_full | Circular RNAs: emerging cancer biomarkers and targets |
| title_fullStr | Circular RNAs: emerging cancer biomarkers and targets |
| title_full_unstemmed | Circular RNAs: emerging cancer biomarkers and targets |
| title_short | Circular RNAs: emerging cancer biomarkers and targets |
| title_sort | circular rnas emerging cancer biomarkers and targets |
| topic | CircRNA Cancer ceRNA Biomarker Target |
| url | http://link.springer.com/article/10.1186/s13046-017-0624-z |
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