Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders?
Target identification is essential for developing novel therapeutic strategies in diseases. Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein-2, is a member of the α-arrestin protein family and is regulated by several cellular stress factors. TXNIP overexpression cou...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.955128/full |
| _version_ | 1818487024578985984 |
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| author | Na Jiang Jinjin Liu Jinjin Liu Conghui Guan Conghui Guan Chengxu Ma Jinyang An Xulei Tang Xulei Tang |
| author_facet | Na Jiang Jinjin Liu Jinjin Liu Conghui Guan Conghui Guan Chengxu Ma Jinyang An Xulei Tang Xulei Tang |
| author_sort | Na Jiang |
| collection | DOAJ |
| description | Target identification is essential for developing novel therapeutic strategies in diseases. Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein-2, is a member of the α-arrestin protein family and is regulated by several cellular stress factors. TXNIP overexpression coupled with thioredoxin inhibits its antioxidant functions, thereby increasing oxidative stress. TXNIP is directly involved in inflammatory activation by interacting with Nod-like receptor protein 3 inflammasome. Bone metabolic disorders are associated with aging, oxidative stress, and inflammation. They are characterized by an imbalance between bone formation involving osteoblasts and bone resorption by osteoclasts, and by chondrocyte destruction. The role of TXNIP in bone metabolic diseases has been extensively investigated. Here, we discuss the roles of TXNIP in the regulatory mechanisms of transcription and protein levels and summarize its involvement in bone metabolic disorders such as osteoporosis, osteoarthritis, and rheumatoid arthritis. TXNIP is expressed in osteoblasts, osteoclasts, and chondrocytes and affects the differentiation and functioning of skeletal cells through both redox-dependent and -independent regulatory mechanisms. Therefore, TXNIP is a potential regulatory and functional factor in bone metabolism and a possible new target for the treatment of bone metabolism-related diseases. |
| first_indexed | 2024-12-10T16:31:35Z |
| format | Article |
| id | doaj.art-3e19ac9de23145c1937fc7f966d2282e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T16:31:35Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3e19ac9de23145c1937fc7f966d2282e2022-12-22T01:41:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.955128955128Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders?Na Jiang0Jinjin Liu1Jinjin Liu2Conghui Guan3Conghui Guan4Chengxu Ma5Jinyang An6Xulei Tang7Xulei Tang8The First Clinical Medical College of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou, ChinaDepartment of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou, ChinaDepartment of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou, ChinaDepartment of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, ChinaTarget identification is essential for developing novel therapeutic strategies in diseases. Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein-2, is a member of the α-arrestin protein family and is regulated by several cellular stress factors. TXNIP overexpression coupled with thioredoxin inhibits its antioxidant functions, thereby increasing oxidative stress. TXNIP is directly involved in inflammatory activation by interacting with Nod-like receptor protein 3 inflammasome. Bone metabolic disorders are associated with aging, oxidative stress, and inflammation. They are characterized by an imbalance between bone formation involving osteoblasts and bone resorption by osteoclasts, and by chondrocyte destruction. The role of TXNIP in bone metabolic diseases has been extensively investigated. Here, we discuss the roles of TXNIP in the regulatory mechanisms of transcription and protein levels and summarize its involvement in bone metabolic disorders such as osteoporosis, osteoarthritis, and rheumatoid arthritis. TXNIP is expressed in osteoblasts, osteoclasts, and chondrocytes and affects the differentiation and functioning of skeletal cells through both redox-dependent and -independent regulatory mechanisms. Therefore, TXNIP is a potential regulatory and functional factor in bone metabolism and a possible new target for the treatment of bone metabolism-related diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2022.955128/fullThioredoxin-interacting proteinosteoporosisosteoarthritisrheumatoid arthritisosteoblastsosteoclasts |
| spellingShingle | Na Jiang Jinjin Liu Jinjin Liu Conghui Guan Conghui Guan Chengxu Ma Jinyang An Xulei Tang Xulei Tang Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? Frontiers in Immunology Thioredoxin-interacting protein osteoporosis osteoarthritis rheumatoid arthritis osteoblasts osteoclasts |
| title | Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? |
| title_full | Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? |
| title_fullStr | Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? |
| title_full_unstemmed | Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? |
| title_short | Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? |
| title_sort | thioredoxin interacting protein a new therapeutic target in bone metabolism disorders |
| topic | Thioredoxin-interacting protein osteoporosis osteoarthritis rheumatoid arthritis osteoblasts osteoclasts |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.955128/full |
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