SMAD4 and TGFβ are architects of inverse genetic programs during fate determination of antiviral CTLs

SMAD4 and TGFβ are architects of inverse genetic programs during fate determination of antiviral CTLs

Transforming growth factor β (TGFβ) is an important differentiation factor for cytotoxic T lymphocytes (CTLs) and alters the expression levels of several of homing receptors during infection. SMAD4 is part of the canonical signaling network used by members of the transforming growth factor family. F...

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Bibliographic Details
Main Authors: Karthik Chandiran, Jenny E Suarez-Ramirez, Yinghong Hu, Evan R Jellison, Zeynep Ugur, Jun Siong Low, Bryan McDonald, Susan M Kaech, Linda S Cauley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
cytotoxic T lymphocyte
SMAD4
TGFβ
CD8 T cell differentiation
CD8 memory
CD8 T cells
Online Access:https://elifesciences.org/articles/76457

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