Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report
Background: Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults. Brugada syndrome caused by propafenone intoxication has been noted rarely in the literature. We report a rare case, Brugada phenocopy due to propaf...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2017-10-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=1745 |
| _version_ | 1828025147430273024 |
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| author | Mehmet Emre Arı Filiz Ekici |
| author_facet | Mehmet Emre Arı Filiz Ekici |
| author_sort | Mehmet Emre Arı |
| collection | DOAJ |
| description | Background: Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults. Brugada syndrome caused by propafenone intoxication has been noted rarely in the literature. We report a rare case, Brugada phenocopy due to propafenone intoxication and its treatment.
Case Report: A 15-year-old girl having a seizure was brought to the emergency room. She took 1.5 g propafenone (Rythmol, Abbott, Chicago, IL, USA) for suicidal intention. She had metabolic acidosis. Long QRS interval and ST elevation in leads V1 through V3 were seen on electrocardiography. After bicarbonate infusion for 4 hours, haemodynamic and neurologic findings were recovered, and all electrocardiography abnormalities disappeared. The Brugada-like electrocardiography pattern was not recognized in her surface and 24-hour Holter electrocardiography at follow-up. Ajmaline challenge test was negative 2 weeks later.
Conclusion: Absence of symptoms and documented ventricular tachycardia, negative challenge test, and a negative family history demonstrated that the Brugada phenocopy was a transient finding in this case and related to propafenone intoxication |
| first_indexed | 2024-04-10T12:55:51Z |
| format | Article |
| id | doaj.art-3e1b0adc981841d383508c7a83523ef3 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:55:51Z |
| publishDate | 2017-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-3e1b0adc981841d383508c7a83523ef32023-02-15T16:13:29ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312017-10-0134547347510.4274/balkanmedj.2016.1185Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case ReportMehmet Emre Arı0Filiz Ekici1Departments of Pediatric Cardiology, Ankara Children’s Hematology and Oncology Research and Training Hospital, Ankara, TurkeyDepartments of Pediatric Cardiology, Ankara Children’s Hematology and Oncology Research and Training Hospital, Ankara, TurkeyBackground: Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults. Brugada syndrome caused by propafenone intoxication has been noted rarely in the literature. We report a rare case, Brugada phenocopy due to propafenone intoxication and its treatment. Case Report: A 15-year-old girl having a seizure was brought to the emergency room. She took 1.5 g propafenone (Rythmol, Abbott, Chicago, IL, USA) for suicidal intention. She had metabolic acidosis. Long QRS interval and ST elevation in leads V1 through V3 were seen on electrocardiography. After bicarbonate infusion for 4 hours, haemodynamic and neurologic findings were recovered, and all electrocardiography abnormalities disappeared. The Brugada-like electrocardiography pattern was not recognized in her surface and 24-hour Holter electrocardiography at follow-up. Ajmaline challenge test was negative 2 weeks later. Conclusion: Absence of symptoms and documented ventricular tachycardia, negative challenge test, and a negative family history demonstrated that the Brugada phenocopy was a transient finding in this case and related to propafenone intoxicationhttp://balkanmedicaljournal.org/text.php?lang=en&id=1745Brugada-like electrocardiography patternpropafenonechildrenBrugada phenocopy |
| spellingShingle | Mehmet Emre Arı Filiz Ekici Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report Balkan Medical Journal Brugada-like electrocardiography pattern propafenone children Brugada phenocopy |
| title | Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report |
| title_full | Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report |
| title_fullStr | Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report |
| title_full_unstemmed | Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report |
| title_short | Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report |
| title_sort | brugada phenocopy induced by propafenone overdose and successful treatment a case report |
| topic | Brugada-like electrocardiography pattern propafenone children Brugada phenocopy |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=1745 |
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