DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity
Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver failure). We describe a case of DILI in a 9-month-o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hygeia Press di Corridori Marinella
2013-04-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/56 |
| _version_ | 1828767526135267328 |
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| author | Anna Paola Pinna Gabriella Locci Maria Furno Daniela Fanni Gavino Faa Anna Maria Nurchi |
| author_facet | Anna Paola Pinna Gabriella Locci Maria Furno Daniela Fanni Gavino Faa Anna Maria Nurchi |
| author_sort | Anna Paola Pinna |
| collection | DOAJ |
| description | Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver failure). We describe a case of DILI in a 9-month-old infant caused by chronic therapy with phenobarbital. |
| first_indexed | 2024-12-11T07:27:40Z |
| format | Article |
| id | doaj.art-3e1bd64d6db948d0ac39f27caacb813a |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-11T07:27:40Z |
| publishDate | 2013-04-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-3e1bd64d6db948d0ac39f27caacb813a2022-12-22T01:15:55ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922013-04-0121939510.7363/02011441DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicityAnna Paola Pinna0Gabriella Locci1Maria Furno2Daniela Fanni3Gavino Faa4Anna Maria Nurchi5Department of Pediatrics and Clinical Medicine, AOU and University of CagliariDepartment of Pathology, AOU and University of CagliariDepartment of Pediatrics and Clinical Medicine, AOU and University of CagliariDepartment of Pathology, AOU and University of CagliariDepartment of Pathology, AOU and University of CagliariDepartment of Pediatrics and Clinical Medicine, AOU and University of CagliariPhenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver failure). We describe a case of DILI in a 9-month-old infant caused by chronic therapy with phenobarbital.https://www.jpnim.com/index.php/jpnim/article/view/56diliinfantphenobarbitalcyp3a4 |
| spellingShingle | Anna Paola Pinna Gabriella Locci Maria Furno Daniela Fanni Gavino Faa Anna Maria Nurchi DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity Journal of Pediatric and Neonatal Individualized Medicine dili infant phenobarbital cyp3a4 |
| title | DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity |
| title_full | DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity |
| title_fullStr | DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity |
| title_full_unstemmed | DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity |
| title_short | DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity |
| title_sort | dili drug induced liver injury in a 9 month old infant a rare case of phenobarbital induced hepatotoxicity |
| topic | dili infant phenobarbital cyp3a4 |
| url | https://www.jpnim.com/index.php/jpnim/article/view/56 |
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