Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon.
BACKGROUND: Plasmodium vivax is responsible for a significant proportion of malaria cases worldwide and is increasingly reported as a cause of severe disease. The objective of this study was to characterize severe vivax disease among children hospitalized in intensive care units (ICUs) in the Wester...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3327677?pdf=render |
_version_ | 1811214708439515136 |
---|---|
author | Ellen Fátima Caetano Lança Belisa Maria Lopes Magalhães Sheila Vitor-Silva André Machado Siqueira Silvana Gomes Benzecry Márcia Almeida Araújo Alexandre Connor O'Brien Quique Bassat Marcus Vinícius Guimarães Lacerda |
author_facet | Ellen Fátima Caetano Lança Belisa Maria Lopes Magalhães Sheila Vitor-Silva André Machado Siqueira Silvana Gomes Benzecry Márcia Almeida Araújo Alexandre Connor O'Brien Quique Bassat Marcus Vinícius Guimarães Lacerda |
author_sort | Ellen Fátima Caetano Lança |
collection | DOAJ |
description | BACKGROUND: Plasmodium vivax is responsible for a significant proportion of malaria cases worldwide and is increasingly reported as a cause of severe disease. The objective of this study was to characterize severe vivax disease among children hospitalized in intensive care units (ICUs) in the Western Brazilian Amazon, and to identify risk factors associated with disease severity. METHODS AND FINDINGS: In this retrospective study, clinical records of 34 children, 0-14 years of age hospitalized in the 11 public pediatric and neonatal ICUs of the Manaus area, were reviewed. P. falciparum monoinfection or P. falciparum/P. vivax mixed infection was diagnosed by microscopy in 10 cases, while P. vivax monoinfection was confirmed in the remaining 24 cases. Two of the 24 patients with P. vivax monoinfection died. Respiratory distress, shock and severe anemia were the most frequent complications associated with P. vivax infection. Ninety-one children hospitalized with P. vivax monoinfections but not requiring ICU were consecutively recruited in a tertiary care hospital for infectious diseases to serve as a reference population (comparators). Male sex (p = 0.039), age less than five years (p = 0.028), parasitemia greater than 500/mm(3) (p = 0.018), and the presence of any acute (p = 0.023) or chronic (p = 0.017) co-morbidity were independently associated with ICU admission. At least one of the WHO severity criteria for malaria (formerly validated for P. falciparum) was present in 23/24 (95.8%) of the patients admitted to the ICU and in 17/91 (18.7%) of controls, making these criteria a good predictor of ICU admission (p = 0.001). The only investigated criterion not associated with ICU admission was hyperbilirubinemia (p = 0.513)]. CONCLUSIONS: Our study points to the importance of P. vivax-associated severe disease in children, causing 72.5% of the malaria admissions to pediatric ICUs. WHO severity criteria demonstrated good sensitivity in predicting severe P. vivax infection in this small case series. |
first_indexed | 2024-04-12T06:10:27Z |
format | Article |
id | doaj.art-3e1c630b87324519b25e42448e04c75d |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-04-12T06:10:27Z |
publishDate | 2012-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-3e1c630b87324519b25e42448e04c75d2022-12-22T03:44:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3540610.1371/journal.pone.0035406Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon.Ellen Fátima Caetano LançaBelisa Maria Lopes MagalhãesSheila Vitor-SilvaAndré Machado SiqueiraSilvana Gomes BenzecryMárcia Almeida Araújo AlexandreConnor O'BrienQuique BassatMarcus Vinícius Guimarães LacerdaBACKGROUND: Plasmodium vivax is responsible for a significant proportion of malaria cases worldwide and is increasingly reported as a cause of severe disease. The objective of this study was to characterize severe vivax disease among children hospitalized in intensive care units (ICUs) in the Western Brazilian Amazon, and to identify risk factors associated with disease severity. METHODS AND FINDINGS: In this retrospective study, clinical records of 34 children, 0-14 years of age hospitalized in the 11 public pediatric and neonatal ICUs of the Manaus area, were reviewed. P. falciparum monoinfection or P. falciparum/P. vivax mixed infection was diagnosed by microscopy in 10 cases, while P. vivax monoinfection was confirmed in the remaining 24 cases. Two of the 24 patients with P. vivax monoinfection died. Respiratory distress, shock and severe anemia were the most frequent complications associated with P. vivax infection. Ninety-one children hospitalized with P. vivax monoinfections but not requiring ICU were consecutively recruited in a tertiary care hospital for infectious diseases to serve as a reference population (comparators). Male sex (p = 0.039), age less than five years (p = 0.028), parasitemia greater than 500/mm(3) (p = 0.018), and the presence of any acute (p = 0.023) or chronic (p = 0.017) co-morbidity were independently associated with ICU admission. At least one of the WHO severity criteria for malaria (formerly validated for P. falciparum) was present in 23/24 (95.8%) of the patients admitted to the ICU and in 17/91 (18.7%) of controls, making these criteria a good predictor of ICU admission (p = 0.001). The only investigated criterion not associated with ICU admission was hyperbilirubinemia (p = 0.513)]. CONCLUSIONS: Our study points to the importance of P. vivax-associated severe disease in children, causing 72.5% of the malaria admissions to pediatric ICUs. WHO severity criteria demonstrated good sensitivity in predicting severe P. vivax infection in this small case series.http://europepmc.org/articles/PMC3327677?pdf=render |
spellingShingle | Ellen Fátima Caetano Lança Belisa Maria Lopes Magalhães Sheila Vitor-Silva André Machado Siqueira Silvana Gomes Benzecry Márcia Almeida Araújo Alexandre Connor O'Brien Quique Bassat Marcus Vinícius Guimarães Lacerda Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. PLoS ONE |
title | Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. |
title_full | Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. |
title_fullStr | Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. |
title_full_unstemmed | Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. |
title_short | Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. |
title_sort | risk factors and characterization of plasmodium vivax associated admissions to pediatric intensive care units in the brazilian amazon |
url | http://europepmc.org/articles/PMC3327677?pdf=render |
work_keys_str_mv | AT ellenfatimacaetanolanca riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT belisamarialopesmagalhaes riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT sheilavitorsilva riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT andremachadosiqueira riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT silvanagomesbenzecry riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT marciaalmeidaaraujoalexandre riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT connorobrien riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT quiquebassat riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon AT marcusviniciusguimaraeslacerda riskfactorsandcharacterizationofplasmodiumvivaxassociatedadmissionstopediatricintensivecareunitsinthebrazilianamazon |