Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study)
Objective: Identify anthropometric trajectories among subjects with type 2 diabetes mellitus (T2DM), and associate them with glycaemic control. Methods: Prospective study including 268 community-dwelling participants with T2DM (34% women, mean age 68.7 ± 8.9 years) followed for 10.7 years (range: 8....
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335521001637 |
| _version_ | 1819138024056815616 |
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| author | Pauline Ducraux Gérard Waeber Pedro Marques-Vidal |
| author_facet | Pauline Ducraux Gérard Waeber Pedro Marques-Vidal |
| author_sort | Pauline Ducraux |
| collection | DOAJ |
| description | Objective: Identify anthropometric trajectories among subjects with type 2 diabetes mellitus (T2DM), and associate them with glycaemic control. Methods: Prospective study including 268 community-dwelling participants with T2DM (34% women, mean age 68.7 ± 8.9 years) followed for 10.7 years (range: 8.8–13.6 years). T2DM control was considered for 1) fasting plasma glucose (FPG) < 7.0 mmol/L, or 2) HbA1c < 7.0% (53 nmol/mol). Changes in weight or waist and weight variability were considered. Results: One half (FPG) and one third (HbA1c) of participants presented with uncontrolled T2DM. Half of the participants presented with obesity and 75% with abdominal obesity. During follow-up, half of the participants maintained their weight, 25% gained > 5 kg, and 25% lost < 5 kg; almost half increased their waist by > 5 cm. Using FPG as criterion, participants who lost > 5 cm waist were more likely to be controlled: multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI): 3.10 (1.23–7.78). Participants with controlled T2DM also presented with a higher weight variability: multivariable adjusted mean ± standard error 4.8 ± 0.3 vs. 3.9 ± 0.3 kg, p = 0.028. Using HbA1c as criterion, participants who lost > 5 kg were less likely to be controlled: OR and (95% CI): 0.35 (0.18–0.66). Similar findings were obtained when restricting the analysis to participants who were diabetic throughout the whole study period. Conclusion: In a Swiss community-based sample of participants with T2DM, T2DM control rates could be implemented. Neither weight nor waist variability was significantly and consistently associated with T2DM control. |
| first_indexed | 2024-12-22T11:00:11Z |
| format | Article |
| id | doaj.art-3e1c6b98e41945a089e0e04f2d40dcf0 |
| institution | Directory Open Access Journal |
| issn | 2211-3355 |
| language | English |
| last_indexed | 2024-12-22T11:00:11Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj.art-3e1c6b98e41945a089e0e04f2d40dcf02022-12-21T18:28:31ZengElsevierPreventive Medicine Reports2211-33552021-09-0123101473Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study)Pauline Ducraux0Gérard Waeber1Pedro Marques-Vidal2Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, 46 rue du Bugnon, 1011 Lausanne, SwitzerlandDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, 46 rue du Bugnon, 1011 Lausanne, SwitzerlandCorresponding author at: Department of Medicine, Internal Medicine, Lausanne University Hospital, Office BH10-642, Rue du Bugnon 46, 1011 Lausanne, Switzerland.; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, 46 rue du Bugnon, 1011 Lausanne, SwitzerlandObjective: Identify anthropometric trajectories among subjects with type 2 diabetes mellitus (T2DM), and associate them with glycaemic control. Methods: Prospective study including 268 community-dwelling participants with T2DM (34% women, mean age 68.7 ± 8.9 years) followed for 10.7 years (range: 8.8–13.6 years). T2DM control was considered for 1) fasting plasma glucose (FPG) < 7.0 mmol/L, or 2) HbA1c < 7.0% (53 nmol/mol). Changes in weight or waist and weight variability were considered. Results: One half (FPG) and one third (HbA1c) of participants presented with uncontrolled T2DM. Half of the participants presented with obesity and 75% with abdominal obesity. During follow-up, half of the participants maintained their weight, 25% gained > 5 kg, and 25% lost < 5 kg; almost half increased their waist by > 5 cm. Using FPG as criterion, participants who lost > 5 cm waist were more likely to be controlled: multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI): 3.10 (1.23–7.78). Participants with controlled T2DM also presented with a higher weight variability: multivariable adjusted mean ± standard error 4.8 ± 0.3 vs. 3.9 ± 0.3 kg, p = 0.028. Using HbA1c as criterion, participants who lost > 5 kg were less likely to be controlled: OR and (95% CI): 0.35 (0.18–0.66). Similar findings were obtained when restricting the analysis to participants who were diabetic throughout the whole study period. Conclusion: In a Swiss community-based sample of participants with T2DM, T2DM control rates could be implemented. Neither weight nor waist variability was significantly and consistently associated with T2DM control.http://www.sciencedirect.com/science/article/pii/S2211335521001637DiabetesDiabetes managementWeightWeight variabilityWaistEpidemiology |
| spellingShingle | Pauline Ducraux Gérard Waeber Pedro Marques-Vidal Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study) Preventive Medicine Reports Diabetes Diabetes management Weight Weight variability Waist Epidemiology |
| title | Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study) |
| title_full | Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study) |
| title_fullStr | Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study) |
| title_full_unstemmed | Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study) |
| title_short | Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study) |
| title_sort | do weight trajectories influence diabetes control a prospective study in switzerland colaus study |
| topic | Diabetes Diabetes management Weight Weight variability Waist Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2211335521001637 |
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