Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control
Adolescence is defined by puberty and represents a period characterized by neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have characterized age-related changes, the extent to which puberty influences maturation of fronto-striatal netw...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929322001268 |
| _version_ | 1811292164766826496 |
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| author | Amar Ojha Ashley C. Parr William Foran Finnegan J. Calabro Beatriz Luna |
| author_facet | Amar Ojha Ashley C. Parr William Foran Finnegan J. Calabro Beatriz Luna |
| author_sort | Amar Ojha |
| collection | DOAJ |
| description | Adolescence is defined by puberty and represents a period characterized by neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have characterized age-related changes, the extent to which puberty influences maturation of fronto-striatal networks is less known. Here, we combine two longitudinal datasets to characterize the role of puberty in the development of fronto-striatal resting-state functional connectivity (rsFC) and its relationship to inhibitory control in 106 10–18-year-olds. Beyond age effects, we found that puberty was related to decreases in rsFC between the caudate and the anterior vmPFC, rostral and ventral ACC, and v/dlPFC, as well as with rsFC increases between the dlPFC and nucleus accumbens (NAcc) across males and females. Stronger caudate rsFC with the dlPFC and vlPFC during early puberty was associated with worse inhibitory control and slower correct responses, respectively, whereas by late puberty, stronger vlPFC rsFC with the dorsal striatum was associated with faster correct responses. Taken together, our findings suggest that certain fronto-striatal connections are associated with pubertal maturation beyond age effects, which, in turn are related to inhibitory control. We discuss implications of puberty-related fronto-striatal maturation to further our understanding of pubertal effects related to adolescent cognitive and affective neurodevelopment. |
| first_indexed | 2024-04-13T04:41:21Z |
| format | Article |
| id | doaj.art-3e1cc401ef70415b907822965d5d8520 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-04-13T04:41:21Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-3e1cc401ef70415b907822965d5d85202022-12-22T03:01:59ZengElsevierDevelopmental Cognitive Neuroscience1878-92932022-12-0158101183Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory controlAmar Ojha0Ashley C. Parr1William Foran2Finnegan J. Calabro3Beatriz Luna4Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Correspondence to: Laboratory of Neurocognitive Development, University of Pittsburgh, 121 Meyran Ave, Pittsburgh, PA 15213, USA.Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USACenter for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USACenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USAAdolescence is defined by puberty and represents a period characterized by neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have characterized age-related changes, the extent to which puberty influences maturation of fronto-striatal networks is less known. Here, we combine two longitudinal datasets to characterize the role of puberty in the development of fronto-striatal resting-state functional connectivity (rsFC) and its relationship to inhibitory control in 106 10–18-year-olds. Beyond age effects, we found that puberty was related to decreases in rsFC between the caudate and the anterior vmPFC, rostral and ventral ACC, and v/dlPFC, as well as with rsFC increases between the dlPFC and nucleus accumbens (NAcc) across males and females. Stronger caudate rsFC with the dlPFC and vlPFC during early puberty was associated with worse inhibitory control and slower correct responses, respectively, whereas by late puberty, stronger vlPFC rsFC with the dorsal striatum was associated with faster correct responses. Taken together, our findings suggest that certain fronto-striatal connections are associated with pubertal maturation beyond age effects, which, in turn are related to inhibitory control. We discuss implications of puberty-related fronto-striatal maturation to further our understanding of pubertal effects related to adolescent cognitive and affective neurodevelopment.http://www.sciencedirect.com/science/article/pii/S1878929322001268AdolescencePubertyResting-state functional connectivityInhibitory control |
| spellingShingle | Amar Ojha Ashley C. Parr William Foran Finnegan J. Calabro Beatriz Luna Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control Developmental Cognitive Neuroscience Adolescence Puberty Resting-state functional connectivity Inhibitory control |
| title | Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control |
| title_full | Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control |
| title_fullStr | Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control |
| title_full_unstemmed | Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control |
| title_short | Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control |
| title_sort | puberty contributes to adolescent development of fronto striatal functional connectivity supporting inhibitory control |
| topic | Adolescence Puberty Resting-state functional connectivity Inhibitory control |
| url | http://www.sciencedirect.com/science/article/pii/S1878929322001268 |
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