PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway

PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway

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PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrat...

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Bibliographic Details
Main Authors:	Wei Zhang, Shengqing Lv, Jun Liu, Zhenle Zang, Junyi Yin, Ning An, Hui Yang, Yechun Song
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Genética 2014-10-01
Series:	Genetics and Molecular Biology
Subjects:	EZH2 malignant gliomas PCI-24781 PIK3K/Akt/mTOR signaling pathway
Online Access:	http://www.scielo.br/pdf/gmb/v37n4/20130279.pdf

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