Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China
Objective We aimed to establish an easy-to-use screening questionnaire with risk factors and suspected symptoms of COPD for primary health care settings. Methods Based on a nationwide epidemiological study of pulmonary health among adults in mainland China (China Pulmonary Health, CPH study) between...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | COPD |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15412555.2022.2042504 |
| _version_ | 1827595116879020032 |
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| author | Dingyi Wang Guohui Fan Sinan Wu Ting Yang Jianying Xu Lan Yang Jianping Zhao Xiangyan Zhang Chunxue Bai Jian Kang Pixin Ran Huahao Shen Fuqiang Wen Kewu Huang Yahong Chen Tieying Sun Guangliang Shan Yingxiang Lin Guodong Xu Ruiying Wang Zhihong Shi Yongjian Xu Xianwei Ye Yuanlin Song Qiuyue Wang Yumin Zhou Wen Li Liren Ding Chun Wan Wanzhen Yao Yanfei Guo Fei Xiao Yong Lu Xiaoxia Peng Biao Zhang Dan Xiao Zuomin Wang Xiaoning Bu Hong Zhang Xiaolei Zhang Li An Shu Zhang Jianguo Zhu Zhixin Cao Qingyuan Zhan Yuanhua Yang Lirong Liang Huaping Dai Bin Cao Jiang He Chen Wang for the China Pulmonary Health (CPH) Study Group |
| author_facet | Dingyi Wang Guohui Fan Sinan Wu Ting Yang Jianying Xu Lan Yang Jianping Zhao Xiangyan Zhang Chunxue Bai Jian Kang Pixin Ran Huahao Shen Fuqiang Wen Kewu Huang Yahong Chen Tieying Sun Guangliang Shan Yingxiang Lin Guodong Xu Ruiying Wang Zhihong Shi Yongjian Xu Xianwei Ye Yuanlin Song Qiuyue Wang Yumin Zhou Wen Li Liren Ding Chun Wan Wanzhen Yao Yanfei Guo Fei Xiao Yong Lu Xiaoxia Peng Biao Zhang Dan Xiao Zuomin Wang Xiaoning Bu Hong Zhang Xiaolei Zhang Li An Shu Zhang Jianguo Zhu Zhixin Cao Qingyuan Zhan Yuanhua Yang Lirong Liang Huaping Dai Bin Cao Jiang He Chen Wang for the China Pulmonary Health (CPH) Study Group |
| author_sort | Dingyi Wang |
| collection | DOAJ |
| description | Objective We aimed to establish an easy-to-use screening questionnaire with risk factors and suspected symptoms of COPD for primary health care settings. Methods Based on a nationwide epidemiological study of pulmonary health among adults in mainland China (China Pulmonary Health, CPH study) between 2012 and 2015, participants ≥40 years who completed the questionnaire and spirometry tests were recruited and randomly divided into development set and validation set by the ratio of 2:1. Parameters including sex, age, BMI, residence, education, smoking status, smoking pack-years, biomass exposure, parental history of respiratory diseases and daily respiratory symptoms were initially selected for the development of scoring system. Receiver operating characteristic (ROC) curve, area under curve (AUC), positive and negative predictive values were calculated in development set and validation set. Results After random split by 2:1 ratio, 22443 individuals were assigned to development set and 11221 to validation set. Ten variables were significantly associated with COPD independently in development set after a stepwise selection by multivariable logistic model and used to develop scoring system. The scoring system yielded good discrimination, as measured by AUC of 0.7737, and in the validation set, the AUC was 0.7711. When applying a cutoff point of ≥16, the sensitivity in development set was 0.69 (0.67 − 0.71); specificity 0.72 (0.71 − 0.73), PPV 0.25 (0.24 − 0.26) and NPV 0.94 (0.94 − 0.95). Conclusion We developed and validated a comprehensive screening questionnaire, COPD-CPHS, with good discrimination. The score system still needs to be validated by large cohort in the future. Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2022.2042504 . |
| first_indexed | 2024-03-09T02:47:10Z |
| format | Article |
| id | doaj.art-3e212c5158fe4d829f9c9dc79b91c44a |
| institution | Directory Open Access Journal |
| issn | 1541-2555 1541-2563 |
| language | English |
| last_indexed | 2024-03-09T02:47:10Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj.art-3e212c5158fe4d829f9c9dc79b91c44a2023-12-05T16:09:50ZengTaylor & Francis GroupCOPD1541-25551541-25632022-12-0119111812410.1080/15412555.2022.20425042042504Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in ChinaDingyi Wang0Guohui Fan1Sinan Wu2Ting Yang3Jianying Xu4Lan Yang5Jianping Zhao6Xiangyan Zhang7Chunxue Bai8Jian Kang9Pixin Ran10Huahao Shen11Fuqiang Wen12Kewu Huang13Yahong Chen14Tieying Sun15Guangliang Shan16Yingxiang Lin17Guodong Xu18Ruiying Wang19Zhihong Shi20Yongjian Xu21Xianwei Ye22Yuanlin Song23Qiuyue Wang24Yumin Zhou25Wen Li26Liren Ding27Chun Wan28Wanzhen Yao29Yanfei Guo30Fei Xiao31Yong Lu32Xiaoxia Peng33Biao Zhang34Dan Xiao35Zuomin Wang36Xiaoning Bu37Hong Zhang38Xiaolei Zhang39Li An40Shu Zhang41Jianguo Zhu42Zhixin Cao43Qingyuan Zhan44Yuanhua Yang45Lirong Liang46Huaping Dai47Bin Cao48Jiang He49Chen Wang50for the China Pulmonary Health (CPH) Study GroupChina-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical SciencesChina-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical SciencesCenter of Respiratory Medicine, China-Japan Friendship HospitalDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship HospitalDepartment of Pulmonary and Critical Care Medicine, Shanxi Bethune HospitalDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pulmonary and Critical Care Medicine, Guizhou Provincial People’s HospitalDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan UniversityDepartment of Pulmonary and Critical Care Medicine, First Hospital of China Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical UniversityDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of MedicineState Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan UniversityBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Respiratory and Critical Care Medicine, Peking University Third HospitalDepartment of Respiratory and Critical Care Medicine, Beijing HospitalChinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical SciencesBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityChina-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical SciencesDepartment of Pulmonary and Critical Care Medicine, Shanxi Bethune HospitalDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pulmonary and Critical Care Medicine, Guizhou Provincial People’s HospitalDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan UniversityDepartment of Pulmonary and Critical Care Medicine, First Hospital of China Medical UniversityState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical UniversityDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of MedicineDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of MedicineState Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan UniversityDepartment of Respiratory and Critical Care Medicine, Peking University Third HospitalDepartment of Respiratory and Critical Care Medicine, Beijing HospitalNational Center of Gerontology, Beijing HospitalBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthChinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical SciencesTobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship HospitalDepartment of Stomatology, Beijing Chao-Yang Hospital, Capital Medical UniversityBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship HospitalBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityNational Center of Gerontology, Beijing HospitalBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship HospitalBeijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Epidemiology, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship HospitalDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship HospitalDepartment of Epidemiology, Tulane University School of Public Health and Tropical MedicineDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship HospitalObjective We aimed to establish an easy-to-use screening questionnaire with risk factors and suspected symptoms of COPD for primary health care settings. Methods Based on a nationwide epidemiological study of pulmonary health among adults in mainland China (China Pulmonary Health, CPH study) between 2012 and 2015, participants ≥40 years who completed the questionnaire and spirometry tests were recruited and randomly divided into development set and validation set by the ratio of 2:1. Parameters including sex, age, BMI, residence, education, smoking status, smoking pack-years, biomass exposure, parental history of respiratory diseases and daily respiratory symptoms were initially selected for the development of scoring system. Receiver operating characteristic (ROC) curve, area under curve (AUC), positive and negative predictive values were calculated in development set and validation set. Results After random split by 2:1 ratio, 22443 individuals were assigned to development set and 11221 to validation set. Ten variables were significantly associated with COPD independently in development set after a stepwise selection by multivariable logistic model and used to develop scoring system. The scoring system yielded good discrimination, as measured by AUC of 0.7737, and in the validation set, the AUC was 0.7711. When applying a cutoff point of ≥16, the sensitivity in development set was 0.69 (0.67 − 0.71); specificity 0.72 (0.71 − 0.73), PPV 0.25 (0.24 − 0.26) and NPV 0.94 (0.94 − 0.95). Conclusion We developed and validated a comprehensive screening questionnaire, COPD-CPHS, with good discrimination. The score system still needs to be validated by large cohort in the future. Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2022.2042504 .http://dx.doi.org/10.1080/15412555.2022.2042504copdscreeningscoring systemvalidation |
| spellingShingle | Dingyi Wang Guohui Fan Sinan Wu Ting Yang Jianying Xu Lan Yang Jianping Zhao Xiangyan Zhang Chunxue Bai Jian Kang Pixin Ran Huahao Shen Fuqiang Wen Kewu Huang Yahong Chen Tieying Sun Guangliang Shan Yingxiang Lin Guodong Xu Ruiying Wang Zhihong Shi Yongjian Xu Xianwei Ye Yuanlin Song Qiuyue Wang Yumin Zhou Wen Li Liren Ding Chun Wan Wanzhen Yao Yanfei Guo Fei Xiao Yong Lu Xiaoxia Peng Biao Zhang Dan Xiao Zuomin Wang Xiaoning Bu Hong Zhang Xiaolei Zhang Li An Shu Zhang Jianguo Zhu Zhixin Cao Qingyuan Zhan Yuanhua Yang Lirong Liang Huaping Dai Bin Cao Jiang He Chen Wang for the China Pulmonary Health (CPH) Study Group Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China COPD copd screening scoring system validation |
| title | Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China |
| title_full | Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China |
| title_fullStr | Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China |
| title_full_unstemmed | Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China |
| title_short | Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China |
| title_sort | development and validation of a screening questionnaire of copd from a large epidemiological study in china |
| topic | copd screening scoring system validation |
| url | http://dx.doi.org/10.1080/15412555.2022.2042504 |
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