The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor
Coronary arterial disease (CAD) is the leading cause of mortality in the world. Hyperuricemia has recently emerged as a novel independent risk factor of CAD, in addition to the traditional risk factors such as hyperlipidemia, smoking, and obesity. Several clinical studies have shown that hyperuricem...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023033042 |
| _version_ | 1797815561303883776 |
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| author | Kaiyue Li Kongwei Li Qingmei Yao Xiaorong Shui Jing Zheng Yuan He Wei Lei |
| author_facet | Kaiyue Li Kongwei Li Qingmei Yao Xiaorong Shui Jing Zheng Yuan He Wei Lei |
| author_sort | Kaiyue Li |
| collection | DOAJ |
| description | Coronary arterial disease (CAD) is the leading cause of mortality in the world. Hyperuricemia has recently emerged as a novel independent risk factor of CAD, in addition to the traditional risk factors such as hyperlipidemia, smoking, and obesity. Several clinical studies have shown that hyperuricemia is strongly associated with the risk, progression and poor prognosis of CAD, as well as verifying an association with traditional CAD risk factors. Uric acid or enzymes in the uric acid production pathway are associated with inflammation, oxidative stress, regulation of multiple signaling pathways and the renin-angiotensin-aldosterone system (RAAS), and these pathophysiological alterations are currently the main mechanisms of coronary atherosclerosis formation. The risk of death from CAD can be effectively reduced by the uric acid-lowering therapy, but the interventional treatment of uric acid levels in patients with CAD remains controversial due to the diversity of co-morbidities and the complexity of causative factors. In this review, we analyze the association between hyperuricemia and CAD, elucidate the possible mechanisms by which uric acid induces or exacerbates CAD, and discuss the benefits and drawbacks of uric acid-lowering therapy. This review could provide theoretical references for the prevention and management of hyperuricemia-associated CAD. |
| first_indexed | 2024-03-13T08:24:40Z |
| format | Article |
| id | doaj.art-3e216216f4d54821bb450a41d0cef2e7 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:24:40Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-3e216216f4d54821bb450a41d0cef2e72023-05-31T04:46:37ZengElsevierHeliyon2405-84402023-05-0195e16097The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factorKaiyue Li0Kongwei Li1Qingmei Yao2Xiaorong Shui3Jing Zheng4Yuan He5Wei Lei6Guangdong Provincial Engineering Technology Research Center for Molecular Diagnosis and Innovative Drugs Translation of Cardiopulmonary Vascular Diseases, University Joint Laboratory of Guangdong Province and Macao Region on Molecular Targets and Intervention of Cardiovascular Diseases, Department of Precision Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Engineering Technology Research Center for Molecular Diagnosis and Innovative Drugs Translation of Cardiopulmonary Vascular Diseases, University Joint Laboratory of Guangdong Province and Macao Region on Molecular Targets and Intervention of Cardiovascular Diseases, Department of Precision Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China; Cardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Engineering Technology Research Center for Molecular Diagnosis and Innovative Drugs Translation of Cardiopulmonary Vascular Diseases, University Joint Laboratory of Guangdong Province and Macao Region on Molecular Targets and Intervention of Cardiovascular Diseases, Department of Precision Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaLaboratory of Vascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USAGuangdong Provincial Engineering Technology Research Center for Molecular Diagnosis and Innovative Drugs Translation of Cardiopulmonary Vascular Diseases, University Joint Laboratory of Guangdong Province and Macao Region on Molecular Targets and Intervention of Cardiovascular Diseases, Department of Precision Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China; Laboratory of Cardiovascular Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China; Corresponding author. 57 Renmin Southern Road, Xiashan, Zhanjiang, Guangdong 524001, China.Guangdong Provincial Engineering Technology Research Center for Molecular Diagnosis and Innovative Drugs Translation of Cardiopulmonary Vascular Diseases, University Joint Laboratory of Guangdong Province and Macao Region on Molecular Targets and Intervention of Cardiovascular Diseases, Department of Precision Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China; Corresponding author. 57 Renmin Southern Road, Xiashan, Zhanjiang, Guangdong 524001, China.Coronary arterial disease (CAD) is the leading cause of mortality in the world. Hyperuricemia has recently emerged as a novel independent risk factor of CAD, in addition to the traditional risk factors such as hyperlipidemia, smoking, and obesity. Several clinical studies have shown that hyperuricemia is strongly associated with the risk, progression and poor prognosis of CAD, as well as verifying an association with traditional CAD risk factors. Uric acid or enzymes in the uric acid production pathway are associated with inflammation, oxidative stress, regulation of multiple signaling pathways and the renin-angiotensin-aldosterone system (RAAS), and these pathophysiological alterations are currently the main mechanisms of coronary atherosclerosis formation. The risk of death from CAD can be effectively reduced by the uric acid-lowering therapy, but the interventional treatment of uric acid levels in patients with CAD remains controversial due to the diversity of co-morbidities and the complexity of causative factors. In this review, we analyze the association between hyperuricemia and CAD, elucidate the possible mechanisms by which uric acid induces or exacerbates CAD, and discuss the benefits and drawbacks of uric acid-lowering therapy. This review could provide theoretical references for the prevention and management of hyperuricemia-associated CAD.http://www.sciencedirect.com/science/article/pii/S2405844023033042HyperuricemiaCoronary arterial diseaseUric acidAtherosclerosisPathophysiology |
| spellingShingle | Kaiyue Li Kongwei Li Qingmei Yao Xiaorong Shui Jing Zheng Yuan He Wei Lei The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor Heliyon Hyperuricemia Coronary arterial disease Uric acid Atherosclerosis Pathophysiology |
| title | The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor |
| title_full | The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor |
| title_fullStr | The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor |
| title_full_unstemmed | The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor |
| title_short | The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor |
| title_sort | potential relationship of coronary artery disease and hyperuricemia a cardiometabolic risk factor |
| topic | Hyperuricemia Coronary arterial disease Uric acid Atherosclerosis Pathophysiology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023033042 |
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