The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats

The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats

Rationale: Development and progression of cardiovascular diseases, including hypertension, are often associated with impaired nitric oxide synthase (NOS) function and nitric oxide (NO) deficiency. Current treatment strategies to restore NO bioavailability with organic nitrates are hampered by undesi...

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Bibliographic Details
Main Authors: Luciano L. Paulo, Josiane Campos Cruz, Zhengbing Zhuge, Alynne Carvalho-Galvão, Maria C.R. Brandão, Thiago F. Diniz, Sarah McCann Haworth, Petrônio F. Athayde-Filho, Virginia S. Lemos, Jon O. Lundberg, Marcelo F. Montenegro, Valdir A. Braga, Mattias Carlström
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
Nitric oxide
Cardiovascular disease
Hypertension
Organic nitrates
Nitrite
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717307693

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