A systematic approach to orient the human protein–protein interaction network
The directions of most human protein-protein interactions (PPIs) remain unknown. Here, the authors use cancer genomic and drug response data to infer the direction of signal flow in the human PPI network and show that the directed network improves drug target and cancer driver gene prioritization.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10887-6 |
| _version_ | 1818851027701465088 |
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| author | Dana Silverbush Roded Sharan |
| author_facet | Dana Silverbush Roded Sharan |
| author_sort | Dana Silverbush |
| collection | DOAJ |
| description | The directions of most human protein-protein interactions (PPIs) remain unknown. Here, the authors use cancer genomic and drug response data to infer the direction of signal flow in the human PPI network and show that the directed network improves drug target and cancer driver gene prioritization. |
| first_indexed | 2024-12-19T06:58:30Z |
| format | Article |
| id | doaj.art-3e25d3924d584a10ba7554732fedb711 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T06:58:30Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3e25d3924d584a10ba7554732fedb7112022-12-21T20:31:28ZengNature PortfolioNature Communications2041-17232019-07-011011910.1038/s41467-019-10887-6A systematic approach to orient the human protein–protein interaction networkDana Silverbush0Roded Sharan1The Blavatnik School of Computer Science, Tel Aviv UniversityThe Blavatnik School of Computer Science, Tel Aviv UniversityThe directions of most human protein-protein interactions (PPIs) remain unknown. Here, the authors use cancer genomic and drug response data to infer the direction of signal flow in the human PPI network and show that the directed network improves drug target and cancer driver gene prioritization.https://doi.org/10.1038/s41467-019-10887-6 |
| spellingShingle | Dana Silverbush Roded Sharan A systematic approach to orient the human protein–protein interaction network Nature Communications |
| title | A systematic approach to orient the human protein–protein interaction network |
| title_full | A systematic approach to orient the human protein–protein interaction network |
| title_fullStr | A systematic approach to orient the human protein–protein interaction network |
| title_full_unstemmed | A systematic approach to orient the human protein–protein interaction network |
| title_short | A systematic approach to orient the human protein–protein interaction network |
| title_sort | systematic approach to orient the human protein protein interaction network |
| url | https://doi.org/10.1038/s41467-019-10887-6 |
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