Histopathological Study of Central Nervous System Lesions: Emphasizing Association of Neoplasms with ABO Blood Groups
Introduction: The Central Nervous System (CNS) lesions show considerable geographic and racial variations with respect to the incidence and the pattern of distribution of lesions. The ABO blood status is a readily accessible factor in genetic constitution of the patients. It has been shown to be...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9644/23863_CE(RA1)_F(T)_PF1(P_SH)_PFA(P)_PF2(P_SH)_PF3(AG_SS).pdf |
| Summary: | Introduction: The Central Nervous System (CNS) lesions show
considerable geographic and racial variations with respect to
the incidence and the pattern of distribution of lesions. The
ABO blood status is a readily accessible factor in genetic
constitution of the patients. It has been shown to be associated
with many diseases. But the influence of blood group status on
the pathogenesis of brain tumours is still unclear.
Aim: To study various histopathological patterns of CNS lesions
and to evaluate the association of CNS tumours with the
distribution of ABO blood groups in documented cases.
Materials and Methods: In the present study, 147 cases
were analyzed. It was an analytical type of study, done at
JSS Medical College, Mysore, over a period of 2 years and 8
months from January 2009 to August 2011. Histopathology
slides were routinely stained by Haematoxylin and Eosin (H&E)
stain. Special stains were performed in selected cases. Blood
group of the patients and the control group were documented.
Blood group distribution pattern was assessed in relation to
histopathological diagnosis of various CNS tumours.
Results: Histopathological diagnosis of 147 cases included neoplastic lesions (84.35%) and non-neoplastic lesions (15.64%).
Neoplastic lesions (84.35%) constituted the majority, which
included neuroepithelial tumours (29.25%) as predominant
pattern. Non-neoplastic lesions constituted only 15.64%,
which included inflammatory lesion (8.16%) as the predominant
pattern. ABO blood group data was available in 92 cases (84.4%)
of neoplastic lesions, which included 71 cases (48.29%) of
primary CNS neoplasms categorized according to WHO grades.
The control group constituted 21,067 healthy voluntary donors.
Blood group O was the most frequent blood group in neoplastic
lesions (40.21%) and primary CNS neoplasms categorized
according to WHO grades (45.07%). The association between
the CNS neoplasms and ABO blood groups was not statistically
significant (p = 0.055). But a definite change in the pattern of
distribution of ABO blood groups observed between neoplastic
lesions and control groups.
Conclusion: The influence of blood group types on the development of brain tumours appears intriguing and needs to be
well established. Though statistically insignificant, a definite
change in the pattern of distribution of ABO blood groups was
observed between neoplastic lesions and control groups. This
necessitates attention and stratification of patients for effective
management. |
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| ISSN: | 2249-782X 0973-709X |