Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections
BACKGROUND: COVID-19 was introduced by the World Health Organization (WHO) as a global pandemic. The spectrum of symptoms of the disease ranges from a mild cold to death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also con...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2022-02-01
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| Series: | ARYA Atherosclerosis |
| Subjects: | |
| Online Access: | https://arya.mui.ac.ir/article_10786_4a4618c3404aa580d2152d5980b3ba73.pdf |
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| author | Fahimeh Safarnezhad-Tameshkel Nima Motamed Mohammad Hadi Karbalaie-Niya Dhayaneethie Perumal Nader Rezaie Shirin Izadi Mitra Ranjbar Mahdi Yadollahzadeh Behnam Behdad Gholamreza Hemmasi Vahid Kaveh Ali Arash Anoushirvani Mojtaba Malek Behzad Farahani Ramin Eskandari Mahshid Panahi Mandana Rahimi Sepideh Emami Farhad Zamani Mohsen Farrokhpour |
| author_facet | Fahimeh Safarnezhad-Tameshkel Nima Motamed Mohammad Hadi Karbalaie-Niya Dhayaneethie Perumal Nader Rezaie Shirin Izadi Mitra Ranjbar Mahdi Yadollahzadeh Behnam Behdad Gholamreza Hemmasi Vahid Kaveh Ali Arash Anoushirvani Mojtaba Malek Behzad Farahani Ramin Eskandari Mahshid Panahi Mandana Rahimi Sepideh Emami Farhad Zamani Mohsen Farrokhpour |
| author_sort | Fahimeh Safarnezhad-Tameshkel |
| collection | DOAJ |
| description | BACKGROUND: COVID-19 was introduced by the World Health Organization (WHO) as a global pandemic. The spectrum of symptoms of the disease ranges from a mild cold to death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also contribute to cardiac injury. This study was conducted to evaluate the relationship between troponin levels as a cardiac marker and adverse outcomes in this disease.METHODS: The study sample included 438 patients hospitalized with COVID-19; however, the troponin data of 6 patients were not available. The need to be admitted to the intensive care unit (ICU), and death were considered the adverse outcome in patients with COVID-19. Troponin levels were checked in all patients on day 1 and day 3 of hospitalization. Multiple logistic regression analysis was performed to determine whether there was an independent association between the adverse outcomes and troponin enzyme in hospitalized patients with COVID-19.RESULTS: The mean age of patients was 61.29 ± 15.84 years. Among the 432 patients tested on day 1 of hospitalization, 24 patients (5.6%) tested positive (Troponin 1), and among the 303 patients tested on day 3, 13 patients (4.3%) tested positive (Troponin 2). Based on our results, Troponin 1 showed an independent association with both death (3.008 [95%CI = 1.091-8.290]; P = 0.033) and need for ICU admission (8.499 [95%CI = 3.316-21.788]; P < 0.001) in multiple logistic regression analysis. Moreover, the status of Troponin 2 had an independent significant association with both death (4.159 [95%CI = 1.156-14.961]; P = 0.029) and ICU admission (7.796 [95%CI = 1.954-31.097]; P = 0.004).CONCLUSION: Troponin showed a significant association with adverse outcomes in people who were hospitalized with COVID-19. The serial assessment of this enzyme from the time of hospitalization may improve the clinical decision making of clinicians. |
| first_indexed | 2024-04-10T04:18:04Z |
| format | Article |
| id | doaj.art-3e271bcd98f54f86be6cda9a6d2f4b3e |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-04-10T04:18:04Z |
| publishDate | 2022-02-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-3e271bcd98f54f86be6cda9a6d2f4b3e2023-03-11T12:59:30ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382022-02-0117110.22122/arya.v17i0.219110786Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infectionsFahimeh Safarnezhad-Tameshkel0Nima Motamed1Mohammad Hadi Karbalaie-Niya2Dhayaneethie Perumal3Nader Rezaie4Shirin Izadi5Mitra Ranjbar6Mahdi Yadollahzadeh7Behnam Behdad8Gholamreza Hemmasi9Vahid Kaveh10Ali Arash Anoushirvani11Mojtaba Malek12Behzad Farahani13Ramin Eskandari14Mahshid Panahi15Mandana Rahimi16Sepideh Emami17Farhad Zamani18Mohsen Farrokhpour19Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, IranAssociate Professor, Department of Social Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, IranAssistant Professor, Gastrointestinal and Liver Diseases Research Center AND Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, IranAssistant Professor, School of Science, Engineering and Computing, Kingston University, Kingston, United KingdomAssociate Professor, Department of Pulmonology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Pulmonology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranProfessor, Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, IranResident, Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, IranAssociate Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Hematology and Medical Oncology, School of Medicine, Iran University Medical Sciences, Tehran, IranAssociate Professor, Department of Interventional Radiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranAssociate Professor, Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Pathology, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Pathology, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranProfessor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, IranBACKGROUND: COVID-19 was introduced by the World Health Organization (WHO) as a global pandemic. The spectrum of symptoms of the disease ranges from a mild cold to death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also contribute to cardiac injury. This study was conducted to evaluate the relationship between troponin levels as a cardiac marker and adverse outcomes in this disease.METHODS: The study sample included 438 patients hospitalized with COVID-19; however, the troponin data of 6 patients were not available. The need to be admitted to the intensive care unit (ICU), and death were considered the adverse outcome in patients with COVID-19. Troponin levels were checked in all patients on day 1 and day 3 of hospitalization. Multiple logistic regression analysis was performed to determine whether there was an independent association between the adverse outcomes and troponin enzyme in hospitalized patients with COVID-19.RESULTS: The mean age of patients was 61.29 ± 15.84 years. Among the 432 patients tested on day 1 of hospitalization, 24 patients (5.6%) tested positive (Troponin 1), and among the 303 patients tested on day 3, 13 patients (4.3%) tested positive (Troponin 2). Based on our results, Troponin 1 showed an independent association with both death (3.008 [95%CI = 1.091-8.290]; P = 0.033) and need for ICU admission (8.499 [95%CI = 3.316-21.788]; P < 0.001) in multiple logistic regression analysis. Moreover, the status of Troponin 2 had an independent significant association with both death (4.159 [95%CI = 1.156-14.961]; P = 0.029) and ICU admission (7.796 [95%CI = 1.954-31.097]; P = 0.004).CONCLUSION: Troponin showed a significant association with adverse outcomes in people who were hospitalized with COVID-19. The serial assessment of this enzyme from the time of hospitalization may improve the clinical decision making of clinicians.https://arya.mui.ac.ir/article_10786_4a4618c3404aa580d2152d5980b3ba73.pdftroponincovid-19mortality |
| spellingShingle | Fahimeh Safarnezhad-Tameshkel Nima Motamed Mohammad Hadi Karbalaie-Niya Dhayaneethie Perumal Nader Rezaie Shirin Izadi Mitra Ranjbar Mahdi Yadollahzadeh Behnam Behdad Gholamreza Hemmasi Vahid Kaveh Ali Arash Anoushirvani Mojtaba Malek Behzad Farahani Ramin Eskandari Mahshid Panahi Mandana Rahimi Sepideh Emami Farhad Zamani Mohsen Farrokhpour Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections ARYA Atherosclerosis troponin covid-19 mortality |
| title | Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections |
| title_full | Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections |
| title_fullStr | Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections |
| title_full_unstemmed | Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections |
| title_short | Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections |
| title_sort | troponin is a useful marker in clinical decision making in hospitalized patients with covid 19 infections |
| topic | troponin covid-19 mortality |
| url | https://arya.mui.ac.ir/article_10786_4a4618c3404aa580d2152d5980b3ba73.pdf |
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