Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC.
The aim of the present study was to investigate and compare the analgesic and anti-inflammatory activities of hydroalcoholic extracts of bark and leaves of Acacia ferruginea DC. Hydroalcoholic extracts of bark and leaves were evaluated for analgesic activity using hot plate method and acetic acid-in...
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SpringerOpen
2016-03-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314853516000123 |
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| author | Samriti Faujdar Swapnil Sharma Bhawna Sati A.K. Pathak Sarvesh Kumar Paliwal |
| author_facet | Samriti Faujdar Swapnil Sharma Bhawna Sati A.K. Pathak Sarvesh Kumar Paliwal |
| author_sort | Samriti Faujdar |
| collection | DOAJ |
| description | The aim of the present study was to investigate and compare the analgesic and anti-inflammatory activities of hydroalcoholic extracts of bark and leaves of Acacia ferruginea DC. Hydroalcoholic extracts of bark and leaves were evaluated for analgesic activity using hot plate method and acetic acid-induced writhing test, whereas the anti-inflammatory activity was evaluated by carrageenan-induced paw oedema method. Hydroalcoholic extract of the bark at the dose of 50 mg/kg (6.10 ± 0.30) and leaves at a dose of 100 mg/kg (5.72 ± 0.39) after 45 min exhibited significant (P < 0.001) analgesic activity in hot plate test, which was comparable to Tramadol (6.11 ± 0.31) at a dose of 10 mg/kg. However, in acetic acid-induced writhing test, hydroalcoholic extract of both bark (90%) and leaves (90.91%) showed maximum protection from acetic acid at the dose of 100 mg/kg as compared to standard drug (50.91%) at a dose of 5 mg/kg. In the evaluation of anti-inflammatory activity, hydroalcoholic extract of leaves at a dose of 400 mg/kg had significantly (74.68%) inhibited the inflammation as comparable to indomethacin (82.8%) after 3 h of induction of carrageenan. It is concluded that hydroalcoholic extracts of bark and leaves have central analgesic and peripheral analgesic effects, respectively. Both hydroalcoholic extracts of the bark and leaves significantly reduced the paw oedema at a dose of 400 mg/kg and exhibited anti-inflammatory activity. |
| first_indexed | 2024-12-11T19:50:15Z |
| format | Article |
| id | doaj.art-3e292ae7d61e4829b5db85e57b9b582f |
| institution | Directory Open Access Journal |
| issn | 2314-8535 |
| language | English |
| last_indexed | 2024-12-11T19:50:15Z |
| publishDate | 2016-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj.art-3e292ae7d61e4829b5db85e57b9b582f2022-12-22T00:52:47ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85352016-03-0151707810.1016/j.bjbas.2016.02.002Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC.Samriti Faujdar0Swapnil Sharma1Bhawna Sati2A.K. Pathak3Sarvesh Kumar Paliwal4Department of Pharmacy, Banasthali University, Rajasthan 304022, IndiaDepartment of Pharmacy, Banasthali University, Rajasthan 304022, IndiaDepartment of Pharmacy, Banasthali University, Rajasthan 304022, IndiaDepartment of Pharmacy, Barkatullah University, Bhopal, Madhya Pradesh 462001, IndiaDepartment of Pharmacy, Banasthali University, Rajasthan 304022, IndiaThe aim of the present study was to investigate and compare the analgesic and anti-inflammatory activities of hydroalcoholic extracts of bark and leaves of Acacia ferruginea DC. Hydroalcoholic extracts of bark and leaves were evaluated for analgesic activity using hot plate method and acetic acid-induced writhing test, whereas the anti-inflammatory activity was evaluated by carrageenan-induced paw oedema method. Hydroalcoholic extract of the bark at the dose of 50 mg/kg (6.10 ± 0.30) and leaves at a dose of 100 mg/kg (5.72 ± 0.39) after 45 min exhibited significant (P < 0.001) analgesic activity in hot plate test, which was comparable to Tramadol (6.11 ± 0.31) at a dose of 10 mg/kg. However, in acetic acid-induced writhing test, hydroalcoholic extract of both bark (90%) and leaves (90.91%) showed maximum protection from acetic acid at the dose of 100 mg/kg as compared to standard drug (50.91%) at a dose of 5 mg/kg. In the evaluation of anti-inflammatory activity, hydroalcoholic extract of leaves at a dose of 400 mg/kg had significantly (74.68%) inhibited the inflammation as comparable to indomethacin (82.8%) after 3 h of induction of carrageenan. It is concluded that hydroalcoholic extracts of bark and leaves have central analgesic and peripheral analgesic effects, respectively. Both hydroalcoholic extracts of the bark and leaves significantly reduced the paw oedema at a dose of 400 mg/kg and exhibited anti-inflammatory activity.http://www.sciencedirect.com/science/article/pii/S2314853516000123Acacia ferrugineaAnalgesic activityCarrageenanAcetic acid-induced writhingsFlavonoids |
| spellingShingle | Samriti Faujdar Swapnil Sharma Bhawna Sati A.K. Pathak Sarvesh Kumar Paliwal Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC. Beni-Suef University Journal of Basic and Applied Sciences Acacia ferruginea Analgesic activity Carrageenan Acetic acid-induced writhings Flavonoids |
| title | Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC. |
| title_full | Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC. |
| title_fullStr | Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC. |
| title_full_unstemmed | Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC. |
| title_short | Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC. |
| title_sort | comparative analysis of analgesic and anti inflammatory activity of bark and leaves of acacia ferruginea dc |
| topic | Acacia ferruginea Analgesic activity Carrageenan Acetic acid-induced writhings Flavonoids |
| url | http://www.sciencedirect.com/science/article/pii/S2314853516000123 |
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