Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania
Diabetes is characterized by an increased rate of serum glucose due to defects in insulin secretion, insulin action or both conditions. Glucose excesses can lead to extended cellular damage, with the consequence of several infectious and non-infectious skin disorders. The aim of the present study wa...
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MDPI AG
2022-08-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/9/922 |
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| author | Laura Trovato Maddalena Calvo Rocco De Pasquale Guido Scalia Salvatore Oliveri |
| author_facet | Laura Trovato Maddalena Calvo Rocco De Pasquale Guido Scalia Salvatore Oliveri |
| author_sort | Laura Trovato |
| collection | DOAJ |
| description | Diabetes is characterized by an increased rate of serum glucose due to defects in insulin secretion, insulin action or both conditions. Glucose excesses can lead to extended cellular damage, with the consequence of several infectious and non-infectious skin disorders. The aim of the present study was to evaluate the toenail onychomycosis incidence in diabetic patients and healthy ones. The non-interventional, retrospective study was performed at the mycology laboratory of the University hospital “Policlinico-San Marco” in Catania, Italy, for over one year. Nail clippings were collected to perform microscopic and cultural exams, which allowed for the identification of fungal aetiological agents. A total of 715 patients (47 diabetic and 668 non-diabetic patients) were enrolled. In diabetic patients, dermatophytes were the most common cultural isolates (50%), followed by yeasts and moulds in 30.8% and 19.2%, respectively. In non-diabetic patients, the distribution of dermatophytes, yeasts and non-dermatophytic moulds was 67.4%, 5.3% and 27.3%, respectively. According to our results, diabetic patients are more predisposed to nail fungal infection. Our data suggest that dermatological follow-ups should always be performed for diabetic patients. All skin and nail disorders should be carefully monitored to perform a diagnostic confirmation and correct management of diabetic patients. |
| first_indexed | 2024-03-09T23:31:03Z |
| format | Article |
| id | doaj.art-3e29f1e8fe084cf4ae6b589c771e2378 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T23:31:03Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-3e29f1e8fe084cf4ae6b589c771e23782023-11-23T17:09:18ZengMDPI AGJournal of Fungi2309-608X2022-08-018992210.3390/jof8090922Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in CataniaLaura Trovato0Maddalena Calvo1Rocco De Pasquale2Guido Scalia3Salvatore Oliveri4U.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-San Marco”, 95125 Catania, ItalyU.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-San Marco”, 95125 Catania, ItalyUnit of Dermatology, Department of General Surgery and Surgical-Medical Specialties, University of Catania, 95124 Catania, ItalyU.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-San Marco”, 95125 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDiabetes is characterized by an increased rate of serum glucose due to defects in insulin secretion, insulin action or both conditions. Glucose excesses can lead to extended cellular damage, with the consequence of several infectious and non-infectious skin disorders. The aim of the present study was to evaluate the toenail onychomycosis incidence in diabetic patients and healthy ones. The non-interventional, retrospective study was performed at the mycology laboratory of the University hospital “Policlinico-San Marco” in Catania, Italy, for over one year. Nail clippings were collected to perform microscopic and cultural exams, which allowed for the identification of fungal aetiological agents. A total of 715 patients (47 diabetic and 668 non-diabetic patients) were enrolled. In diabetic patients, dermatophytes were the most common cultural isolates (50%), followed by yeasts and moulds in 30.8% and 19.2%, respectively. In non-diabetic patients, the distribution of dermatophytes, yeasts and non-dermatophytic moulds was 67.4%, 5.3% and 27.3%, respectively. According to our results, diabetic patients are more predisposed to nail fungal infection. Our data suggest that dermatological follow-ups should always be performed for diabetic patients. All skin and nail disorders should be carefully monitored to perform a diagnostic confirmation and correct management of diabetic patients.https://www.mdpi.com/2309-608X/8/9/922onychomycosisdiabetesfungal nail infectionsdermatophytes |
| spellingShingle | Laura Trovato Maddalena Calvo Rocco De Pasquale Guido Scalia Salvatore Oliveri Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania Journal of Fungi onychomycosis diabetes fungal nail infections dermatophytes |
| title | Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania |
| title_full | Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania |
| title_fullStr | Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania |
| title_full_unstemmed | Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania |
| title_short | Prevalence of Onychomycosis in Diabetic Patients: A Case-Control Study Performed at University Hospital Policlinico in Catania |
| title_sort | prevalence of onychomycosis in diabetic patients a case control study performed at university hospital policlinico in catania |
| topic | onychomycosis diabetes fungal nail infections dermatophytes |
| url | https://www.mdpi.com/2309-608X/8/9/922 |
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