Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression

Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression

Endoplasmic reticulum (ER) stress is implicated in many chronic diseases, but very little is known about how the unfolded protein response (UPR) responds to persistent ER stress in vivo. Here, we experimentally reconstituted chronic ER stress in the mouse liver, using repeated injection of a low dos...

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Bibliographic Details
Main Authors: Javier A Gomez, D Thomas Rutkowski
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
ER stress
unfolded protein response
mRNA expression
Regulated IRE1-dependent decay
liver
Online Access:https://elifesciences.org/articles/20390

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