Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats
Active avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identi...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/5/659 |
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| author | Katharina Braun Anja Mannewitz Joerg Bock Silke Kreitz Andreas Hess Henning Scheich Jürgen Goldschmidt |
| author_facet | Katharina Braun Anja Mannewitz Joerg Bock Silke Kreitz Andreas Hess Henning Scheich Jürgen Goldschmidt |
| author_sort | Katharina Braun |
| collection | DOAJ |
| description | Active avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identified, the aim of this study was to obtain an overall picture of the brain circuits that are involved in active avoidance learning. In order to obtain a longitudinal assessment of activation patterns in the brain of freely behaving rats during different stages of learning, we applied single-photon emission computed tomography (SPECT). We were able to identify distinct prefrontal cortical, sensory, and limbic circuits that were specifically recruited during the acquisition and retrieval phases of the two-way avoidance learning task. |
| first_indexed | 2024-03-10T11:17:56Z |
| format | Article |
| id | doaj.art-3e2b465286d44ef7aa0b66162680683f |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T11:17:56Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3e2b465286d44ef7aa0b66162680683f2023-11-21T20:16:38ZengMDPI AGBrain Sciences2076-34252021-05-0111565910.3390/brainsci11050659Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving RatsKatharina Braun0Anja Mannewitz1Joerg Bock2Silke Kreitz3Andreas Hess4Henning Scheich5Jürgen Goldschmidt6Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, 39106 Magdeburg, GermanyDepartment of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, 39106 Magdeburg, GermanyCenter for Behavioral Brain Sciences, 39106 Magdeburg, GermanyInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University, 91054 Erlangen, GermanyInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University, 91054 Erlangen, GermanyCenter for Behavioral Brain Sciences, 39106 Magdeburg, GermanyCenter for Behavioral Brain Sciences, 39106 Magdeburg, GermanyActive avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identified, the aim of this study was to obtain an overall picture of the brain circuits that are involved in active avoidance learning. In order to obtain a longitudinal assessment of activation patterns in the brain of freely behaving rats during different stages of learning, we applied single-photon emission computed tomography (SPECT). We were able to identify distinct prefrontal cortical, sensory, and limbic circuits that were specifically recruited during the acquisition and retrieval phases of the two-way avoidance learning task.https://www.mdpi.com/2076-3425/11/5/659functional imagingavoidance learningacquisitionmemory retrievalprefrontal cortexlimbic system |
| spellingShingle | Katharina Braun Anja Mannewitz Joerg Bock Silke Kreitz Andreas Hess Henning Scheich Jürgen Goldschmidt Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats Brain Sciences functional imaging avoidance learning acquisition memory retrieval prefrontal cortex limbic system |
| title | Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats |
| title_full | Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats |
| title_fullStr | Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats |
| title_full_unstemmed | Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats |
| title_short | Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats |
| title_sort | imaging of functional brain circuits during acquisition and memory retrieval in an aversive feedback learning task single photon emission computed tomography of regional cerebral blood flow in freely behaving rats |
| topic | functional imaging avoidance learning acquisition memory retrieval prefrontal cortex limbic system |
| url | https://www.mdpi.com/2076-3425/11/5/659 |
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