Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment
Introduction Epidemiological evidence suggests that both poor cardiovascular fitness and low muscle mass or strength markedly increase the rate of cognitive decline and incident dementia in older adults. Results from exercise trials for the improvement of cognition in older adults with mild cognitiv...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e062059.full |
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| author | Teresa Liu-Ambrose Ulrik Wisløff Maria Fiatarone Singh Yorgi Mavros Perminder S Sachdev Ryan S Falck Dorthe Stensvold Jeff S Coombes Trinidad Valenzuela Nicole Kochan Wei Wen Jeffrey Hausdorff Jiyang Jiang Emily C Smith Matthew Hollings Tess C Hawkins Nicholas J Ashley Natan Feter Guy C Wilson Isabel Hui En Shih Yareni Guerrero Tom Bailey |
| author_facet | Teresa Liu-Ambrose Ulrik Wisløff Maria Fiatarone Singh Yorgi Mavros Perminder S Sachdev Ryan S Falck Dorthe Stensvold Jeff S Coombes Trinidad Valenzuela Nicole Kochan Wei Wen Jeffrey Hausdorff Jiyang Jiang Emily C Smith Matthew Hollings Tess C Hawkins Nicholas J Ashley Natan Feter Guy C Wilson Isabel Hui En Shih Yareni Guerrero Tom Bailey |
| author_sort | Teresa Liu-Ambrose |
| collection | DOAJ |
| description | Introduction Epidemiological evidence suggests that both poor cardiovascular fitness and low muscle mass or strength markedly increase the rate of cognitive decline and incident dementia in older adults. Results from exercise trials for the improvement of cognition in older adults with mild cognitive impairment (MCI) have reported mixed results. This is possibly due to insufficient exercise intensities. The aim of the Balance, Resistance, And INterval (BRAIN) Training Trial is to determine the effects of two forms of exercise, high-intensity aerobic interval training (HIIT) and high-intensity power training (POWER) each compared with a sham exercise control group on cognition in older adults with MCI.Methods and analysis One hundred and sixty community-dwelling older (≥ 60 years) people with MCI have been randomised into the trial. Interventions are delivered supervised 2–3 days per week for 12 months. The primary outcome measured at baseline, 6 and 12 months is performance on a cognitive composite score measuring the executive domain calculated from a combination of computerised (NeuroTrax) and paper-and-pencil tests. Analyses will be performed via repeated measures linear mixed models and generalised linear mixed models of baseline, 6-month and 12-month time points, adjusted for baseline values and covariates selected a priori. Mixed models will be constructed to determine the interaction of GROUP × TIME.Ethics and dissemination Ethical approval was obtained from the University of Sydney (HREC Ref.2017/368), University of Queensland (HREC Ref. 2017/HE000853), University of British Columbia (H16-03309), and Vancouver Coastal Health Research Institute (V16-03309) Human Research Ethics. Dissemination will be via publications, conference presentations, newsletter articles, social media, talks to clinicians and consumers and meetings with health departments/managers.It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT and POWER on subclinical markers of disease.Trial registration number ACTRN12617001440314 Australian New Zealand Clinical Trials Registry. |
| first_indexed | 2024-04-13T03:58:35Z |
| format | Article |
| id | doaj.art-3e2c7ee76d3c449ca542b4c0e67fde28 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-13T03:58:35Z |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-3e2c7ee76d3c449ca542b4c0e67fde282022-12-22T03:03:33ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-062059Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairmentTeresa Liu-Ambrose0Ulrik Wisløff1Maria Fiatarone Singh2Yorgi Mavros3Perminder S Sachdev4Ryan S Falck5Dorthe Stensvold6Jeff S Coombes7Trinidad Valenzuela8Nicole Kochan9Wei Wen10Jeffrey Hausdorff11Jiyang Jiang12Emily C Smith13Matthew Hollings14Tess C Hawkins15Nicholas J Ashley16Natan Feter17Guy C Wilson18Isabel Hui En Shih19Yareni Guerrero20Tom Bailey211 Department of Physical Therapy, The University of British Columbia, Faculty of Medicine, Vancouver, British Columbia, CanadaDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway8 Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, AustraliaUniversity of Sydney, Sydney, New South Wales, AustraliaCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Sydney, Sydney, New South Wales, Australia1 Department of Physical Therapy, The University of British Columbia, Faculty of Medicine, Vancouver, British Columbia, Canadaprofessorprofessorpostdoctoral research associate2University of New South Wales, Sydney, NSW, AustraliaCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Sydney, Sydney, New South Wales, AustraliaCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, IsraelCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Sydney, Sydney, New South Wales, AustraliaHuman Movement and Nutrition Sciences, Faculty of Health and Behavioural Sciences, The University of Queensland, Herston, Queensland, AustraliaSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaPostgraduate Program of Physical Education, Universidade Federal de Pelotas, Pelotas, BrazilSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaHuman Movement and Nutrition Sciences, Faculty of Health and Behavioural Sciences, The University of Queensland, Herston, Queensland, AustraliaIntroduction Epidemiological evidence suggests that both poor cardiovascular fitness and low muscle mass or strength markedly increase the rate of cognitive decline and incident dementia in older adults. Results from exercise trials for the improvement of cognition in older adults with mild cognitive impairment (MCI) have reported mixed results. This is possibly due to insufficient exercise intensities. The aim of the Balance, Resistance, And INterval (BRAIN) Training Trial is to determine the effects of two forms of exercise, high-intensity aerobic interval training (HIIT) and high-intensity power training (POWER) each compared with a sham exercise control group on cognition in older adults with MCI.Methods and analysis One hundred and sixty community-dwelling older (≥ 60 years) people with MCI have been randomised into the trial. Interventions are delivered supervised 2–3 days per week for 12 months. The primary outcome measured at baseline, 6 and 12 months is performance on a cognitive composite score measuring the executive domain calculated from a combination of computerised (NeuroTrax) and paper-and-pencil tests. Analyses will be performed via repeated measures linear mixed models and generalised linear mixed models of baseline, 6-month and 12-month time points, adjusted for baseline values and covariates selected a priori. Mixed models will be constructed to determine the interaction of GROUP × TIME.Ethics and dissemination Ethical approval was obtained from the University of Sydney (HREC Ref.2017/368), University of Queensland (HREC Ref. 2017/HE000853), University of British Columbia (H16-03309), and Vancouver Coastal Health Research Institute (V16-03309) Human Research Ethics. Dissemination will be via publications, conference presentations, newsletter articles, social media, talks to clinicians and consumers and meetings with health departments/managers.It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT and POWER on subclinical markers of disease.Trial registration number ACTRN12617001440314 Australian New Zealand Clinical Trials Registry.https://bmjopen.bmj.com/content/12/12/e062059.full |
| spellingShingle | Teresa Liu-Ambrose Ulrik Wisløff Maria Fiatarone Singh Yorgi Mavros Perminder S Sachdev Ryan S Falck Dorthe Stensvold Jeff S Coombes Trinidad Valenzuela Nicole Kochan Wei Wen Jeffrey Hausdorff Jiyang Jiang Emily C Smith Matthew Hollings Tess C Hawkins Nicholas J Ashley Natan Feter Guy C Wilson Isabel Hui En Shih Yareni Guerrero Tom Bailey Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment BMJ Open |
| title | Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment |
| title_full | Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment |
| title_fullStr | Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment |
| title_full_unstemmed | Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment |
| title_short | Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive impairment |
| title_sort | study protocol for the brain training trial a randomised controlled trial of balance resistance and interval training on cognitive function in older adults with mild cognitive impairment |
| url | https://bmjopen.bmj.com/content/12/12/e062059.full |
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