African Swine Fever Virus Ubiquitin-Conjugating Enzyme Is an Immunomodulator Targeting NF-κB Activation

African Swine Fever Virus Ubiquitin-Conjugating Enzyme Is an Immunomodulator Targeting NF-κB Activation

African swine fever virus (ASFV) is an acute and persistent swine virus with a high economic burden that encodes multiple genes to evade host immune response. In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune...

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Bibliographic Details
Main Authors: Lucía Barrado-Gil, Ana del Puerto, Inmaculada Galindo, Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Carlos Maluquer de Motes, Covadonga Alonso
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
innate immunity
TLR
NF-κB
AP-1
IFN
STING
Online Access:https://www.mdpi.com/1999-4915/13/6/1160

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