Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function
Background: Advanced glycation end-products (AGEs) cause proinflammatory responses and macromolecular damages. Advanced oxidation protein products (AOPPs) are protein biomarkers for oxidative stress. Levels of AGEs and AOPPs increase with the progression of chronic renal dysfunction. Objectives: In...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2019-01-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-8-03.pdf |
| _version_ | 1797827967111397376 |
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| author | Heshmatolah Shahbazian Samaneh Salehipour Bavarsad Hamid Yaghooti Seyyed Mostafa Saadati Samaneh Olapour |
| author_facet | Heshmatolah Shahbazian Samaneh Salehipour Bavarsad Hamid Yaghooti Seyyed Mostafa Saadati Samaneh Olapour |
| author_sort | Heshmatolah Shahbazian |
| collection | DOAJ |
| description | Background: Advanced glycation end-products (AGEs) cause proinflammatory responses and macromolecular damages. Advanced oxidation protein products (AOPPs) are protein biomarkers for oxidative stress. Levels of AGEs and AOPPs increase with the progression of chronic renal dysfunction. Objectives: In this study, we aimed to measure these species in patients with renal transplantation and to analyze their correlation with the measured glomerular filtration rate (GFR) and renal function parameters. Patients and Methods: Eighty renal transplant patients and normal subjects were recruited. GFR was measured by the two-sample plasma method with technetium-99m-labeled diethylenetriaminepentaacetic acid (TC99m-DTPA) clearance. Biochemical measurements included creatinine, cystatin C, urea, total protein, and pentosidine. Serum AGEs were determined using a fluorometric assay and AOPPs were estimated spectrophotometrically. Results: The measured GFR found to be significantly decreased in renal transplant patients compared to the control subjects (P< 0.001). Levels of AGEs, AOPPs, serum creatinine, and cystatin C were increased in renal transplant patients with lower values of measured GFR (mGFR). A significant association between the levels of AGEs species (serum fluorescence and pentosidine) and mGFR when adjusted for creatinine and other risk factors in multiple linear regression model analysis was found (P=0.05 and P=0.001, respectively). Conclusions: This study demonstrated increased levels of pentosidine and AGEs in transplant recipients were associated with decreased mGFR. Their accumulation can be predictive for the progression of chronic allograft loss of function. |
| first_indexed | 2024-04-09T12:56:54Z |
| format | Article |
| id | doaj.art-3e2efa847a1b4737a7a2a48d37ec0718 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:56:54Z |
| publishDate | 2019-01-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-3e2efa847a1b4737a7a2a48d37ec07182023-05-13T11:28:40ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192019-01-0181e03e0310.15171/jnp.2019.03jnp-20180109110136Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney functionHeshmatolah Shahbazian0Samaneh Salehipour Bavarsad1Hamid Yaghooti2Seyyed Mostafa Saadati3Samaneh Olapour4Department of Nephrology, Golestan General Hospital, Diabetes and CKD Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranHyperlipidemia Research Center, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranNuclear Medicine Department, Golestan General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranStudent Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranBackground: Advanced glycation end-products (AGEs) cause proinflammatory responses and macromolecular damages. Advanced oxidation protein products (AOPPs) are protein biomarkers for oxidative stress. Levels of AGEs and AOPPs increase with the progression of chronic renal dysfunction. Objectives: In this study, we aimed to measure these species in patients with renal transplantation and to analyze their correlation with the measured glomerular filtration rate (GFR) and renal function parameters. Patients and Methods: Eighty renal transplant patients and normal subjects were recruited. GFR was measured by the two-sample plasma method with technetium-99m-labeled diethylenetriaminepentaacetic acid (TC99m-DTPA) clearance. Biochemical measurements included creatinine, cystatin C, urea, total protein, and pentosidine. Serum AGEs were determined using a fluorometric assay and AOPPs were estimated spectrophotometrically. Results: The measured GFR found to be significantly decreased in renal transplant patients compared to the control subjects (P< 0.001). Levels of AGEs, AOPPs, serum creatinine, and cystatin C were increased in renal transplant patients with lower values of measured GFR (mGFR). A significant association between the levels of AGEs species (serum fluorescence and pentosidine) and mGFR when adjusted for creatinine and other risk factors in multiple linear regression model analysis was found (P=0.05 and P=0.001, respectively). Conclusions: This study demonstrated increased levels of pentosidine and AGEs in transplant recipients were associated with decreased mGFR. Their accumulation can be predictive for the progression of chronic allograft loss of function.https://nephropathol.com/PDF/jnp-8-03.pdfrenal transplantationadvanced glycation end-productsallograft dysfunctionglomerular filtration rateend-stage renal diseaseoxidative stresschronic kidney disease |
| spellingShingle | Heshmatolah Shahbazian Samaneh Salehipour Bavarsad Hamid Yaghooti Seyyed Mostafa Saadati Samaneh Olapour Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function Journal of Nephropathology renal transplantation advanced glycation end-products allograft dysfunction glomerular filtration rate end-stage renal disease oxidative stress chronic kidney disease |
| title | Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function |
| title_full | Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function |
| title_fullStr | Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function |
| title_full_unstemmed | Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function |
| title_short | Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function |
| title_sort | increased level of advanced glycation end products in renal transplant patients is associated with decreased measured gfr and grafted kidney function |
| topic | renal transplantation advanced glycation end-products allograft dysfunction glomerular filtration rate end-stage renal disease oxidative stress chronic kidney disease |
| url | https://nephropathol.com/PDF/jnp-8-03.pdf |
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