Blueberries’ Impact on Insulin Resistance and Glucose Intolerance
Blueberries are a rich source of polyphenols, which include anthocyanin bioactive compounds. Epidemiological evidence indicates that incorporating blueberries into the diet may lower the risk of developing type 2 diabetes (T2DM). These findings are supported by pre-clinical and clinical studies that...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-11-01
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| Series: | Antioxidants |
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| Online Access: | http://www.mdpi.com/2076-3921/5/4/44 |
| _version_ | 1797706104028790784 |
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| author | April J. Stull |
| author_facet | April J. Stull |
| author_sort | April J. Stull |
| collection | DOAJ |
| description | Blueberries are a rich source of polyphenols, which include anthocyanin bioactive compounds. Epidemiological evidence indicates that incorporating blueberries into the diet may lower the risk of developing type 2 diabetes (T2DM). These findings are supported by pre-clinical and clinical studies that have shown improvements in insulin resistance (i.e., increased insulin sensitivity) after obese and insulin-resistant rodents or humans consumed blueberries. Insulin resistance was assessed by homeostatic model assessment-estimated insulin resistance (HOMA-IR), insulin tolerance tests, and hyperinsulinemic-euglycemic clamps. Additionally, the improvements in glucose tolerance after blueberry consumption were assessed by glucose tolerance tests. However, firm conclusions regarding the anti-diabetic effect of blueberries cannot be drawn due to the small number of existing clinical studies. Although the current evidence is promising, more long-term, randomized, and placebo-controlled trials are needed to establish the role of blueberries in preventing or delaying T2DM. |
| first_indexed | 2024-03-12T05:47:20Z |
| format | Article |
| id | doaj.art-3e2fee8858344716a9bc0bc3ea19aec0 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T05:47:20Z |
| publishDate | 2016-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3e2fee8858344716a9bc0bc3ea19aec02023-09-03T05:32:49ZengMDPI AGAntioxidants2076-39212016-11-01544410.3390/antiox5040044antiox5040044Blueberries’ Impact on Insulin Resistance and Glucose IntoleranceApril J. Stull0Department of Human Ecology, University of Maryland Eastern Shore, Princess Anne, MD 21853, USABlueberries are a rich source of polyphenols, which include anthocyanin bioactive compounds. Epidemiological evidence indicates that incorporating blueberries into the diet may lower the risk of developing type 2 diabetes (T2DM). These findings are supported by pre-clinical and clinical studies that have shown improvements in insulin resistance (i.e., increased insulin sensitivity) after obese and insulin-resistant rodents or humans consumed blueberries. Insulin resistance was assessed by homeostatic model assessment-estimated insulin resistance (HOMA-IR), insulin tolerance tests, and hyperinsulinemic-euglycemic clamps. Additionally, the improvements in glucose tolerance after blueberry consumption were assessed by glucose tolerance tests. However, firm conclusions regarding the anti-diabetic effect of blueberries cannot be drawn due to the small number of existing clinical studies. Although the current evidence is promising, more long-term, randomized, and placebo-controlled trials are needed to establish the role of blueberries in preventing or delaying T2DM.http://www.mdpi.com/2076-3921/5/4/44blueberriesbilberriesstrawberriescranberriesberriesanthocyaninsdiabetesinsulinglucosediabetes |
| spellingShingle | April J. Stull Blueberries’ Impact on Insulin Resistance and Glucose Intolerance Antioxidants blueberries bilberries strawberries cranberries berries anthocyanins diabetes insulin glucose diabetes |
| title | Blueberries’ Impact on Insulin Resistance and Glucose Intolerance |
| title_full | Blueberries’ Impact on Insulin Resistance and Glucose Intolerance |
| title_fullStr | Blueberries’ Impact on Insulin Resistance and Glucose Intolerance |
| title_full_unstemmed | Blueberries’ Impact on Insulin Resistance and Glucose Intolerance |
| title_short | Blueberries’ Impact on Insulin Resistance and Glucose Intolerance |
| title_sort | blueberries impact on insulin resistance and glucose intolerance |
| topic | blueberries bilberries strawberries cranberries berries anthocyanins diabetes insulin glucose diabetes |
| url | http://www.mdpi.com/2076-3921/5/4/44 |
| work_keys_str_mv | AT apriljstull blueberriesimpactoninsulinresistanceandglucoseintolerance |