Patients with papillary thyroid carcinoma associated with high stimulated serum calcitonin levels
Among various substances produced by C-cells, the most important one is calcitonin (CT) that is used for detection, postoperative follow-up and evaluation of individuals at risk of developing medullary thyroid carcinoma (MTC). However, the role of serum CT measurement in the evaluation of thyroid...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2017-10-01
|
| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-17-0085 |
| Summary: | Among various substances produced by C-cells, the most important one is calcitonin (CT) that is used for detection, postoperative
follow-up and evaluation of individuals at risk of developing medullary thyroid carcinoma (MTC). However,
the role of serum CT measurement in the evaluation of thyroid nodules has been widely discussed, and there is still no
consensus about the role of CT in the initial evaluation of all thyroid nodules. Two patients with thyroid nodules whose
fine-needle aspiration results were compatible with benign cytology besides having mildly elevated basal serum calcitonin
levels were reported. Calcitonin responses (peak levels were 313 and 229 pg/mL, respectively) to calcium stimulation test
were compatible with the possible diagnosis of MTC. However, the final diagnosis was papillary thyroid carcinoma of the
thyroid gland. There are limited numbers of case reports showing such an increased serum calcitonin responses to calcium
stimulation test associated with papillary or follicular thyroid carcinoma of the thyroid. We suggest to measure serum
CT level once and in case of normal levels, no further CT measurement is necessary. Physicians should keep in mind that
thyroid carcinomas other than MTCs may also be associated with high serum CT levels. |
|---|---|
| ISSN: | 2052-0573 2052-0573 |