AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.

Inflammation is a multifaceted marker resulting from complex interactions between genetic and lifestyle factors. Emerging evidence suggests Aryl hydrocarbon receptor (AHR) protein may be implicated in the regulation of immune system and inflammatory responses. To investigate whether rs4410790 genoty...

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Main Authors: Jaewon Khil, Soyoun Kim, Minhyeong Lee, Hyeonmin Gil, Seok-Seong Kang, Dong Hoon Lee, Youngeun Kwon, NaNa Keum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290700&type=printable
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author Jaewon Khil
Soyoun Kim
Minhyeong Lee
Hyeonmin Gil
Seok-Seong Kang
Dong Hoon Lee
Youngeun Kwon
NaNa Keum
author_facet Jaewon Khil
Soyoun Kim
Minhyeong Lee
Hyeonmin Gil
Seok-Seong Kang
Dong Hoon Lee
Youngeun Kwon
NaNa Keum
author_sort Jaewon Khil
collection DOAJ
description Inflammation is a multifaceted marker resulting from complex interactions between genetic and lifestyle factors. Emerging evidence suggests Aryl hydrocarbon receptor (AHR) protein may be implicated in the regulation of immune system and inflammatory responses. To investigate whether rs4410790 genotype (TT, TC, CC) near AHR gene is related to serum IgG levels, a marker of chronic inflammation, and whether lifestyle factors modifies the relationship, we conducted a cross-sectional study by recruiting 168 Korean adults. Participants responded to a lifestyle questionnaire and provided oral epithelial cells and blood samples for biomarker assessment. Among these participants, C allele was the minor allele, with the minor allele frequency of 40%. The rs4410790 TT genotype was significantly associated with elevated IgG levels compared with TC/CC genotypes, after adjusting for potential confounders (p = 0.04). The relationship varied significantly by levels of alcohol consumption (P interaction = 0.046) and overweight/obese status (P interaction = 0.02), but not by smoking status (P interaction = 0.64) and coffee consumption (P interaction = 0.55). Specifically, higher IgG levels associated with the TT genotype were evident in frequent drinkers and individuals with BMI≥23kg/m2, but not in their counterparts. Thus, rs4410790 genotype may be associated with IgG levels and the genetic predisposition to higher IgG levels may be mitigated by healthy lifestyle factors like infrequent drinking and healthy weight.
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spelling doaj.art-3e3271694f8046359f8d131ee4fe02ae2023-10-11T05:32:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029070010.1371/journal.pone.0290700AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.Jaewon KhilSoyoun KimMinhyeong LeeHyeonmin GilSeok-Seong KangDong Hoon LeeYoungeun KwonNaNa KeumInflammation is a multifaceted marker resulting from complex interactions between genetic and lifestyle factors. Emerging evidence suggests Aryl hydrocarbon receptor (AHR) protein may be implicated in the regulation of immune system and inflammatory responses. To investigate whether rs4410790 genotype (TT, TC, CC) near AHR gene is related to serum IgG levels, a marker of chronic inflammation, and whether lifestyle factors modifies the relationship, we conducted a cross-sectional study by recruiting 168 Korean adults. Participants responded to a lifestyle questionnaire and provided oral epithelial cells and blood samples for biomarker assessment. Among these participants, C allele was the minor allele, with the minor allele frequency of 40%. The rs4410790 TT genotype was significantly associated with elevated IgG levels compared with TC/CC genotypes, after adjusting for potential confounders (p = 0.04). The relationship varied significantly by levels of alcohol consumption (P interaction = 0.046) and overweight/obese status (P interaction = 0.02), but not by smoking status (P interaction = 0.64) and coffee consumption (P interaction = 0.55). Specifically, higher IgG levels associated with the TT genotype were evident in frequent drinkers and individuals with BMI≥23kg/m2, but not in their counterparts. Thus, rs4410790 genotype may be associated with IgG levels and the genetic predisposition to higher IgG levels may be mitigated by healthy lifestyle factors like infrequent drinking and healthy weight.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290700&type=printable
spellingShingle Jaewon Khil
Soyoun Kim
Minhyeong Lee
Hyeonmin Gil
Seok-Seong Kang
Dong Hoon Lee
Youngeun Kwon
NaNa Keum
AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.
PLoS ONE
title AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.
title_full AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.
title_fullStr AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.
title_full_unstemmed AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.
title_short AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors.
title_sort ahr rs4410790 genotype and igg levels effect modification by lifestyle factors
url https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290700&type=printable
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