Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury
Deep brain stimulation and epidural electrical stimulation of the spinal cord enable locomotion in humans with spinal cord injury (SCI) but the potential synergy between both approaches is unclear. The authors show that a complex technological approach is required to enable volitional walking in rat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22137-9 |
| _version_ | 1818425254141231104 |
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| author | Marco Bonizzato Nicholas D. James Galyna Pidpruzhnykova Natalia Pavlova Polina Shkorbatova Laetitia Baud Cristina Martinez-Gonzalez Jordan W. Squair Jack DiGiovanna Quentin Barraud Silvestro Micera Gregoire Courtine |
| author_facet | Marco Bonizzato Nicholas D. James Galyna Pidpruzhnykova Natalia Pavlova Polina Shkorbatova Laetitia Baud Cristina Martinez-Gonzalez Jordan W. Squair Jack DiGiovanna Quentin Barraud Silvestro Micera Gregoire Courtine |
| author_sort | Marco Bonizzato |
| collection | DOAJ |
| description | Deep brain stimulation and epidural electrical stimulation of the spinal cord enable locomotion in humans with spinal cord injury (SCI) but the potential synergy between both approaches is unclear. The authors show that a complex technological approach is required to enable volitional walking in rats with SCI. |
| first_indexed | 2024-12-14T14:11:01Z |
| format | Article |
| id | doaj.art-3e33fdf15f7148f6ac0e70238e049c1c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:11:01Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3e33fdf15f7148f6ac0e70238e049c1c2022-12-21T22:58:18ZengNature PortfolioNature Communications2041-17232021-03-0112111410.1038/s41467-021-22137-9Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injuryMarco Bonizzato0Nicholas D. James1Galyna Pidpruzhnykova2Natalia Pavlova3Polina Shkorbatova4Laetitia Baud5Cristina Martinez-Gonzalez6Jordan W. Squair7Jack DiGiovannaQuentin Barraud8Silvestro Micera9Gregoire Courtine10Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)Deep brain stimulation and epidural electrical stimulation of the spinal cord enable locomotion in humans with spinal cord injury (SCI) but the potential synergy between both approaches is unclear. The authors show that a complex technological approach is required to enable volitional walking in rats with SCI.https://doi.org/10.1038/s41467-021-22137-9 |
| spellingShingle | Marco Bonizzato Nicholas D. James Galyna Pidpruzhnykova Natalia Pavlova Polina Shkorbatova Laetitia Baud Cristina Martinez-Gonzalez Jordan W. Squair Jack DiGiovanna Quentin Barraud Silvestro Micera Gregoire Courtine Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury Nature Communications |
| title | Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury |
| title_full | Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury |
| title_fullStr | Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury |
| title_full_unstemmed | Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury |
| title_short | Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury |
| title_sort | multi pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury |
| url | https://doi.org/10.1038/s41467-021-22137-9 |
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