Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor
Around 8% of patients diagnosed with sickle cell disease (SCD) are hepatitis C virus (HCV) carriers. Previously, HCV treatment was seldom considered in SCD patients, as the ribavirin-induced hemolysis and interferon-induced cytopenias could lead to more profound anemia. Nowadays, several oral direct...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-10-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/493421 |
| _version_ | 1811201903246180352 |
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| author | Hassan Al Moussawi Abhishek D. Polavarapu Divya Asti Zainab Awada Stephen Mulrooney |
| author_facet | Hassan Al Moussawi Abhishek D. Polavarapu Divya Asti Zainab Awada Stephen Mulrooney |
| author_sort | Hassan Al Moussawi |
| collection | DOAJ |
| description | Around 8% of patients diagnosed with sickle cell disease (SCD) are hepatitis C virus (HCV) carriers. Previously, HCV treatment was seldom considered in SCD patients, as the ribavirin-induced hemolysis and interferon-induced cytopenias could lead to more profound anemia. Nowadays, several oral direct-acting antiviral drugs have been developed and approved by the FDA for hepatitis C treatment. While direct-acting antivirals mitigate many of these risks, their safety and efficacy in SCD patients remains insufficiently explored. Here, we report on successfully treating HCV with ledipasvir/sofosbuvir in a compensated cirrhotic patient with SCD and thalassemia minor. |
| first_indexed | 2024-04-12T02:29:45Z |
| format | Article |
| id | doaj.art-3e3761025a2d4083a91771ed9414a757 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-12T02:29:45Z |
| publishDate | 2018-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-3e3761025a2d4083a91771ed9414a7572022-12-22T03:51:49ZengKarger PublishersCase Reports in Gastroenterology1662-06312018-10-0112362963210.1159/000493421493421Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia MinorHassan Al MoussawiAbhishek D. PolavarapuDivya AstiZainab AwadaStephen MulrooneyAround 8% of patients diagnosed with sickle cell disease (SCD) are hepatitis C virus (HCV) carriers. Previously, HCV treatment was seldom considered in SCD patients, as the ribavirin-induced hemolysis and interferon-induced cytopenias could lead to more profound anemia. Nowadays, several oral direct-acting antiviral drugs have been developed and approved by the FDA for hepatitis C treatment. While direct-acting antivirals mitigate many of these risks, their safety and efficacy in SCD patients remains insufficiently explored. Here, we report on successfully treating HCV with ledipasvir/sofosbuvir in a compensated cirrhotic patient with SCD and thalassemia minor.https://www.karger.com/Article/FullText/493421Hepatitis C virusLedipasvir/sofosbuvirSickle cell disease |
| spellingShingle | Hassan Al Moussawi Abhishek D. Polavarapu Divya Asti Zainab Awada Stephen Mulrooney Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor Case Reports in Gastroenterology Hepatitis C virus Ledipasvir/sofosbuvir Sickle cell disease |
| title | Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor |
| title_full | Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor |
| title_fullStr | Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor |
| title_full_unstemmed | Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor |
| title_short | Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor |
| title_sort | successful treatment of hepatitis c virus by ledipasvir sofosbuvir in a cirrhotic patient with sickle cell disease and thalassemia minor |
| topic | Hepatitis C virus Ledipasvir/sofosbuvir Sickle cell disease |
| url | https://www.karger.com/Article/FullText/493421 |
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