The Versatile Role of miR-21 in Renal Homeostasis and Diseases
MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/21/3525 |
| _version_ | 1797468698940801024 |
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| author | Romain Larrue Sandy Fellah Cynthia Van der Hauwaert Marie-Flore Hennino Michaël Perrais Arnaud Lionet François Glowacki Nicolas Pottier Christelle Cauffiez |
| author_facet | Romain Larrue Sandy Fellah Cynthia Van der Hauwaert Marie-Flore Hennino Michaël Perrais Arnaud Lionet François Glowacki Nicolas Pottier Christelle Cauffiez |
| author_sort | Romain Larrue |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset and progression of various forms of acute and chronic renal disorders. In recent years, miR-21, one of the best-characterized miRNAs to date, has received much attention in renal physiology in particular given its high degree of conservation and expression in kidneys, as well as its potent pathogenic role in various debilitating renal diseases. This review summarizes the current knowledge on miR-21’s involvement in both renal homeostasis and diseases, in particular its double-edged-sword role in acute versus chronic kidney injuries. Finally, we also discuss the potential of miR-21 as a biomarker and therapeutic target in renal diseases. |
| first_indexed | 2024-03-09T19:11:12Z |
| format | Article |
| id | doaj.art-3e3828f377014c3796af4702c6194295 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T19:11:12Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3e3828f377014c3796af4702c61942952023-11-24T04:10:10ZengMDPI AGCells2073-44092022-11-011121352510.3390/cells11213525The Versatile Role of miR-21 in Renal Homeostasis and DiseasesRomain Larrue0Sandy Fellah1Cynthia Van der Hauwaert2Marie-Flore Hennino3Michaël Perrais4Arnaud Lionet5François Glowacki6Nicolas Pottier7Christelle Cauffiez8Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceCH Valenciennes, Service de Néphrologie, F-59300 Valenciennes, FranceUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceCHU Lille, Service de Néphrologie, F-59000 Lille, FranceUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277—CANTHER—Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, FranceMicroRNAs (miRNAs) are small, non-coding RNA species that control gene expression and confer robustness to biological processes. Over the last two decades, their important roles during kidney development, homeostasis and the treatment of diseases have been established, in particular during the onset and progression of various forms of acute and chronic renal disorders. In recent years, miR-21, one of the best-characterized miRNAs to date, has received much attention in renal physiology in particular given its high degree of conservation and expression in kidneys, as well as its potent pathogenic role in various debilitating renal diseases. This review summarizes the current knowledge on miR-21’s involvement in both renal homeostasis and diseases, in particular its double-edged-sword role in acute versus chronic kidney injuries. Finally, we also discuss the potential of miR-21 as a biomarker and therapeutic target in renal diseases.https://www.mdpi.com/2073-4409/11/21/3525microRNAkidneycancerfibrosis |
| spellingShingle | Romain Larrue Sandy Fellah Cynthia Van der Hauwaert Marie-Flore Hennino Michaël Perrais Arnaud Lionet François Glowacki Nicolas Pottier Christelle Cauffiez The Versatile Role of miR-21 in Renal Homeostasis and Diseases Cells microRNA kidney cancer fibrosis |
| title | The Versatile Role of miR-21 in Renal Homeostasis and Diseases |
| title_full | The Versatile Role of miR-21 in Renal Homeostasis and Diseases |
| title_fullStr | The Versatile Role of miR-21 in Renal Homeostasis and Diseases |
| title_full_unstemmed | The Versatile Role of miR-21 in Renal Homeostasis and Diseases |
| title_short | The Versatile Role of miR-21 in Renal Homeostasis and Diseases |
| title_sort | versatile role of mir 21 in renal homeostasis and diseases |
| topic | microRNA kidney cancer fibrosis |
| url | https://www.mdpi.com/2073-4409/11/21/3525 |
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