Hyperhidrosis and the risk of being treated for skin infections
Background A few studies have described an increased prevalence of skin infections in individuals with hyperhidrosis compared to others. However, it remains uncertain whether hyperhidrosis is an independent risk factor for skin infections. Objective To compare the risk of skin infections in individu...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-05-01
|
| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2021.1944971 |
| _version_ | 1797683526460506112 |
|---|---|
| author | Mattias A. S. Henning Kristina S. Ibler Sisse R. Ostrowski Christian Erikstrup Kaspar R. Nielsen Mie T. Bruun Henrik Hjalgrim Henrik Ullum Maria Didriksen Khoa M. Dinh Klaus Rostgaard Ole B. Pedersen Gregor B. Jemec |
| author_facet | Mattias A. S. Henning Kristina S. Ibler Sisse R. Ostrowski Christian Erikstrup Kaspar R. Nielsen Mie T. Bruun Henrik Hjalgrim Henrik Ullum Maria Didriksen Khoa M. Dinh Klaus Rostgaard Ole B. Pedersen Gregor B. Jemec |
| author_sort | Mattias A. S. Henning |
| collection | DOAJ |
| description | Background A few studies have described an increased prevalence of skin infections in individuals with hyperhidrosis compared to others. However, it remains uncertain whether hyperhidrosis is an independent risk factor for skin infections. Objective To compare the risk of skin infections in individuals with and without hyperhidrosis. Methods In this retrospective cohort study, data on hyperhidrosis were collected from the Danish Blood Donor Study. Blood donors included in 2010–2019 were followed from inclusion until December 2019. Data on redeemed prescriptions against skin infections were collected from the National Prescription Register. The intensity of prescription-use by hyperhidrosis status was assessed in Andersen–Gill models. Results Overall, 4,176 (9.6%) of 43,477 blood donors had self-reported hyperhidrosis and 437 (0.34%) of 127,823 blood donors had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with the use of antibiotic prescriptions (adjusted hazard ratio = 1.21; 95% confidence interval 1.00–1.45, p = 0.047). Hospital diagnosed hyperhidrosis was associated with the use of antibiotic (adjusted hazard ratio = 1.33; 95% confidence interval 1.03–1.68, p = 0.028) and topical antifungal prescriptions (adjusted hazard ratio = 1.43; 95% confidence interval 1.04–1.97, p = 0.027). Conclusions Hyperhidrosis is associated with the use of prescriptions for antibiotics and topical antifungals. This suggests a clinically relevant association between hyperhidrosis and skin infections. |
| first_indexed | 2024-03-12T00:15:49Z |
| format | Article |
| id | doaj.art-3e3a6237b80b427fb3b9ea9e1c4b5835 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:49Z |
| publishDate | 2022-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-3e3a6237b80b427fb3b9ea9e1c4b58352023-09-15T14:28:51ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-05-013342263226910.1080/09546634.2021.19449711944971Hyperhidrosis and the risk of being treated for skin infectionsMattias A. S. Henning0Kristina S. Ibler1Sisse R. Ostrowski2Christian Erikstrup3Kaspar R. Nielsen4Mie T. Bruun5Henrik Hjalgrim6Henrik Ullum7Maria Didriksen8Khoa M. Dinh9Klaus Rostgaard10Ole B. Pedersen11Gregor B. Jemec12Department of Dermatology, Zealand University Hospital, University of CopenhagenDepartment of Dermatology, Zealand University Hospital, University of CopenhagenDepartment of Clinical Immunology, Rigshospitalet, University of CopenhagenDepartment of Clinical Immunology, Aarhus University HospitalDepartment of Clinical Immunology, Aalborg UniversityDepartment of Clinical Immunology, Odense University HospitalDanish Cancer Society Research CenterDepartment of Clinical Immunology, Rigshospitalet, University of CopenhagenDepartment of Clinical Immunology, Rigshospitalet, University of CopenhagenDepartment of Clinical Immunology, Aarhus University HospitalDepartment of Epidemiology Research, Statens Serum InstitutDepartment of Clinical Immunology, Zealand University Hospital. University of CopenhagenDepartment of Dermatology, Zealand University Hospital, University of CopenhagenBackground A few studies have described an increased prevalence of skin infections in individuals with hyperhidrosis compared to others. However, it remains uncertain whether hyperhidrosis is an independent risk factor for skin infections. Objective To compare the risk of skin infections in individuals with and without hyperhidrosis. Methods In this retrospective cohort study, data on hyperhidrosis were collected from the Danish Blood Donor Study. Blood donors included in 2010–2019 were followed from inclusion until December 2019. Data on redeemed prescriptions against skin infections were collected from the National Prescription Register. The intensity of prescription-use by hyperhidrosis status was assessed in Andersen–Gill models. Results Overall, 4,176 (9.6%) of 43,477 blood donors had self-reported hyperhidrosis and 437 (0.34%) of 127,823 blood donors had hospital diagnosed hyperhidrosis. Self-reported hyperhidrosis was associated with the use of antibiotic prescriptions (adjusted hazard ratio = 1.21; 95% confidence interval 1.00–1.45, p = 0.047). Hospital diagnosed hyperhidrosis was associated with the use of antibiotic (adjusted hazard ratio = 1.33; 95% confidence interval 1.03–1.68, p = 0.028) and topical antifungal prescriptions (adjusted hazard ratio = 1.43; 95% confidence interval 1.04–1.97, p = 0.027). Conclusions Hyperhidrosis is associated with the use of prescriptions for antibiotics and topical antifungals. This suggests a clinically relevant association between hyperhidrosis and skin infections.http://dx.doi.org/10.1080/09546634.2021.1944971antibioticsantifungalscohort studyhyperhidrosis |
| spellingShingle | Mattias A. S. Henning Kristina S. Ibler Sisse R. Ostrowski Christian Erikstrup Kaspar R. Nielsen Mie T. Bruun Henrik Hjalgrim Henrik Ullum Maria Didriksen Khoa M. Dinh Klaus Rostgaard Ole B. Pedersen Gregor B. Jemec Hyperhidrosis and the risk of being treated for skin infections Journal of Dermatological Treatment antibiotics antifungals cohort study hyperhidrosis |
| title | Hyperhidrosis and the risk of being treated for skin infections |
| title_full | Hyperhidrosis and the risk of being treated for skin infections |
| title_fullStr | Hyperhidrosis and the risk of being treated for skin infections |
| title_full_unstemmed | Hyperhidrosis and the risk of being treated for skin infections |
| title_short | Hyperhidrosis and the risk of being treated for skin infections |
| title_sort | hyperhidrosis and the risk of being treated for skin infections |
| topic | antibiotics antifungals cohort study hyperhidrosis |
| url | http://dx.doi.org/10.1080/09546634.2021.1944971 |
| work_keys_str_mv | AT mattiasashenning hyperhidrosisandtheriskofbeingtreatedforskininfections AT kristinasibler hyperhidrosisandtheriskofbeingtreatedforskininfections AT sisserostrowski hyperhidrosisandtheriskofbeingtreatedforskininfections AT christianerikstrup hyperhidrosisandtheriskofbeingtreatedforskininfections AT kasparrnielsen hyperhidrosisandtheriskofbeingtreatedforskininfections AT mietbruun hyperhidrosisandtheriskofbeingtreatedforskininfections AT henrikhjalgrim hyperhidrosisandtheriskofbeingtreatedforskininfections AT henrikullum hyperhidrosisandtheriskofbeingtreatedforskininfections AT mariadidriksen hyperhidrosisandtheriskofbeingtreatedforskininfections AT khoamdinh hyperhidrosisandtheriskofbeingtreatedforskininfections AT klausrostgaard hyperhidrosisandtheriskofbeingtreatedforskininfections AT olebpedersen hyperhidrosisandtheriskofbeingtreatedforskininfections AT gregorbjemec hyperhidrosisandtheriskofbeingtreatedforskininfections |