Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy
Purpose: To report the outcomes of allograft limbal stem cell transplantation for recurrent gelatinous drop-like corneal dystrophy (GDLD). Methods: In this non-comparative interventional case series, 4 eyes of 3 consecutive patients with recurrent GDLD underwent allograft limbal stem cell transplan...
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| Format: | Article |
| Language: | English |
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Knowledge E
2013-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2013;volume=8;issue=2;spage=107;epage=112;aulast=Movahedan |
| _version_ | 1797991045703663616 |
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| author | Hossein Movahedan Hamid Reza Anvari-Ardekani Mohammad Hossien Nowroozzadeh |
| author_facet | Hossein Movahedan Hamid Reza Anvari-Ardekani Mohammad Hossien Nowroozzadeh |
| author_sort | Hossein Movahedan |
| collection | DOAJ |
| description | Purpose: To report the outcomes of allograft limbal stem cell transplantation for recurrent gelatinous drop-like corneal dystrophy (GDLD).
Methods: In this non-comparative interventional case series, 4 eyes of 3 consecutive patients with recurrent GDLD underwent allograft limbal stem cell transplantation. Two eyes underwent concomitant penetrating keratoplasty while the other two underwent simultaneous superficial keratectomy. Main outcome measures were best spectacle corrected visual acuity, intraocular pressure and corneal clarity.
Results: Patient age ranged from 28 to 63 years. Mean follow-up after surgery was 23±10 (median, 22; range, 12-36) months. Mean visual acuity improved from 2.70±0.61 logMAR preoperatively to 1.05±0.06 logMAR at final postoperative visit (P=0.066). Intraocular pressure was normal in all eyes at baseline and remained within normal limits at all postoperative visits. All corneas remained smooth and clear during the follow-up period with no episode of rejection or recurrence. All patients maintained ambulatory vision until final follow-up.
Conclusion: The present study provides further evidence that limbal stem cell transplantation may be an effective therapeutic alternative in patients with GDLD. |
| first_indexed | 2024-04-11T08:46:15Z |
| format | Article |
| id | doaj.art-3e3a69315eac445c8d907818a4814998 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T08:46:15Z |
| publishDate | 2013-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-3e3a69315eac445c8d907818a48149982022-12-22T04:33:58ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2013-01-0182107112Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal DystrophyHossein MovahedanHamid Reza Anvari-ArdekaniMohammad Hossien NowroozzadehPurpose: To report the outcomes of allograft limbal stem cell transplantation for recurrent gelatinous drop-like corneal dystrophy (GDLD). Methods: In this non-comparative interventional case series, 4 eyes of 3 consecutive patients with recurrent GDLD underwent allograft limbal stem cell transplantation. Two eyes underwent concomitant penetrating keratoplasty while the other two underwent simultaneous superficial keratectomy. Main outcome measures were best spectacle corrected visual acuity, intraocular pressure and corneal clarity. Results: Patient age ranged from 28 to 63 years. Mean follow-up after surgery was 23±10 (median, 22; range, 12-36) months. Mean visual acuity improved from 2.70±0.61 logMAR preoperatively to 1.05±0.06 logMAR at final postoperative visit (P=0.066). Intraocular pressure was normal in all eyes at baseline and remained within normal limits at all postoperative visits. All corneas remained smooth and clear during the follow-up period with no episode of rejection or recurrence. All patients maintained ambulatory vision until final follow-up. Conclusion: The present study provides further evidence that limbal stem cell transplantation may be an effective therapeutic alternative in patients with GDLD.http://www.jovr.org/article.asp?issn=2008-322X;year=2013;volume=8;issue=2;spage=107;epage=112;aulast=MovahedanCorneal Dystrophy; Gelatinous Drop-Like Dystrophy; Limbal Stem Cell Transplantation |
| spellingShingle | Hossein Movahedan Hamid Reza Anvari-Ardekani Mohammad Hossien Nowroozzadeh Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy Journal of Ophthalmic & Vision Research Corneal Dystrophy; Gelatinous Drop-Like Dystrophy; Limbal Stem Cell Transplantation |
| title | Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy |
| title_full | Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy |
| title_fullStr | Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy |
| title_full_unstemmed | Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy |
| title_short | Limbal Stem Cell Transplantation for Gelatinous Drop-like Corneal Dystrophy |
| title_sort | limbal stem cell transplantation for gelatinous drop like corneal dystrophy |
| topic | Corneal Dystrophy; Gelatinous Drop-Like Dystrophy; Limbal Stem Cell Transplantation |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2013;volume=8;issue=2;spage=107;epage=112;aulast=Movahedan |
| work_keys_str_mv | AT hosseinmovahedan limbalstemcelltransplantationforgelatinousdroplikecornealdystrophy AT hamidrezaanvariardekani limbalstemcelltransplantationforgelatinousdroplikecornealdystrophy AT mohammadhossiennowroozzadeh limbalstemcelltransplantationforgelatinousdroplikecornealdystrophy |