Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational study
Background Assessing the extent of lung involvement is important for the triage and care of COVID‐19 pneumonia. We sought to determine the utility of point‐of‐care ultrasound (POCUS) for characterizing lung involvement and, thereby, clinical risk determination in COVID‐19 pneumonia. Methods This mul...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
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| Series: | Journal of the American College of Emergency Physicians Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/emp2.12429 |
| _version_ | 1819021614881177600 |
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| author | Arthur W. E. Lieveld Bram Kok Kaoutar Azijli Frederik H. Schuit Peter M. van deVen Chris L. deKorte Robin Nijveldt Frederik M. A. vanden Heuvel Bernd P. Teunissen Wouter Hoefsloot Prabath W. B. Nanayakkara Frank H. Bosch |
| author_facet | Arthur W. E. Lieveld Bram Kok Kaoutar Azijli Frederik H. Schuit Peter M. van deVen Chris L. deKorte Robin Nijveldt Frederik M. A. vanden Heuvel Bernd P. Teunissen Wouter Hoefsloot Prabath W. B. Nanayakkara Frank H. Bosch |
| author_sort | Arthur W. E. Lieveld |
| collection | DOAJ |
| description | Background Assessing the extent of lung involvement is important for the triage and care of COVID‐19 pneumonia. We sought to determine the utility of point‐of‐care ultrasound (POCUS) for characterizing lung involvement and, thereby, clinical risk determination in COVID‐19 pneumonia. Methods This multicenter, prospective, observational study included patients with COVID‐19 who received 12‐zone lung ultrasound and chest computed tomography (CT) scanning in the emergency department (ED). We defined lung disease severity using the lung ultrasound score (LUS) and chest CT severity score (CTSS). We assessed the association between the LUS and poor outcome (ICU admission or 30‐day all‐cause mortality). We also assessed the association between the LUS and hospital length of stay. We examined the ability of the LUS to differentiate between disease severity groups. Lastly, we estimated the correlation between the LUS and CTSS and the interrater agreement for the LUS. We handled missing data by multiple imputation with chained equations and predictive mean matching. Results We included 114 patients treated between March 19, 2020, and May 4, 2020. An LUS ≥12 was associated with a poor outcome within 30 days (hazard ratio [HR], 5.59; 95% confidence interval [CI], 1.26–24.80; P = 0.02). Admission duration was shorter in patients with an LUS <12 (adjusted HR, 2.24; 95% CI, 1.47–3.40; P < 0.001). Mean LUS differed between disease severity groups: no admission, 6.3 (standard deviation [SD], 4.4); hospital/ward, 13.1 (SD, 6.4); and ICU, 18.0 (SD, 5.0). The LUS was able to discriminate between ED discharge and hospital admission excellently, with an area under the curve of 0.83 (95% CI, 0.75–0.91). Interrater agreement for the LUS was strong: κ = 0.88 (95% CI, 0.77–0.95). Correlation between the LUS and CTSS was strong: κ = 0.60 (95% CI, 0.48–0.71). Conclusions We showed that baseline lung ultrasound ‐ is associated with poor outcomes, admission duration, and disease severity. The LUS also correlates well with CTSS. Point‐of‐care lung ultrasound may aid the risk stratification and triage of patients with COVID‐19 at the ED. |
| first_indexed | 2024-12-21T04:09:55Z |
| format | Article |
| id | doaj.art-3e3ac55e4c0343649deed8fd9e997a9b |
| institution | Directory Open Access Journal |
| issn | 2688-1152 |
| language | English |
| last_indexed | 2024-12-21T04:09:55Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American College of Emergency Physicians Open |
| spelling | doaj.art-3e3ac55e4c0343649deed8fd9e997a9b2022-12-21T19:16:30ZengWileyJournal of the American College of Emergency Physicians Open2688-11522021-06-0123n/an/a10.1002/emp2.12429Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational studyArthur W. E. Lieveld0Bram Kok1Kaoutar Azijli2Frederik H. Schuit3Peter M. van deVen4Chris L. deKorte5Robin Nijveldt6Frederik M. A. vanden Heuvel7Bernd P. Teunissen8Wouter Hoefsloot9Prabath W. B. Nanayakkara10Frank H. Bosch11Section General and Acute Internal Medicine Department of Internal Medicine Amsterdam Public Health Research Institute Amsterdam University Medical Center Amsterdam The NetherlandsSection Acute Internal Medicine, Department of Internal Medicine Radboud University Medical Center Nijmegen The NetherlandsSection Emergency Medicine Emergency Department Amsterdam Public Health Research Institute, Amsterdam University Medical Center Amsterdam The NetherlandsSection General and Acute Internal Medicine Department of Internal Medicine Amsterdam Public Health Research Institute Amsterdam University Medical Center Amsterdam The NetherlandsDepartment of Epidemiology and Data Science Amsterdam University Medical Center Amsterdam The NetherlandsMedical UltraSound Imaging Center Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen The NetherlandsDepartment of Cardiology Radboud University Medical Center Nijmegen The NetherlandsDepartment of Cardiology Radboud University Medical Center Nijmegen The NetherlandsDepartment of Radiology & Nuclear Medicine Amsterdam University Medical Center Amsterdam The NetherlandsRadboudumc Center for Infectious Diseases Department of Pulmonary Diseases Radboud University Medical Center Nijmegen The NetherlandsSection General and Acute Internal Medicine Department of Internal Medicine Amsterdam Public Health Research Institute Amsterdam University Medical Center Amsterdam The NetherlandsSection Acute Internal Medicine, Department of Internal Medicine Radboud University Medical Center Nijmegen The NetherlandsBackground Assessing the extent of lung involvement is important for the triage and care of COVID‐19 pneumonia. We sought to determine the utility of point‐of‐care ultrasound (POCUS) for characterizing lung involvement and, thereby, clinical risk determination in COVID‐19 pneumonia. Methods This multicenter, prospective, observational study included patients with COVID‐19 who received 12‐zone lung ultrasound and chest computed tomography (CT) scanning in the emergency department (ED). We defined lung disease severity using the lung ultrasound score (LUS) and chest CT severity score (CTSS). We assessed the association between the LUS and poor outcome (ICU admission or 30‐day all‐cause mortality). We also assessed the association between the LUS and hospital length of stay. We examined the ability of the LUS to differentiate between disease severity groups. Lastly, we estimated the correlation between the LUS and CTSS and the interrater agreement for the LUS. We handled missing data by multiple imputation with chained equations and predictive mean matching. Results We included 114 patients treated between March 19, 2020, and May 4, 2020. An LUS ≥12 was associated with a poor outcome within 30 days (hazard ratio [HR], 5.59; 95% confidence interval [CI], 1.26–24.80; P = 0.02). Admission duration was shorter in patients with an LUS <12 (adjusted HR, 2.24; 95% CI, 1.47–3.40; P < 0.001). Mean LUS differed between disease severity groups: no admission, 6.3 (standard deviation [SD], 4.4); hospital/ward, 13.1 (SD, 6.4); and ICU, 18.0 (SD, 5.0). The LUS was able to discriminate between ED discharge and hospital admission excellently, with an area under the curve of 0.83 (95% CI, 0.75–0.91). Interrater agreement for the LUS was strong: κ = 0.88 (95% CI, 0.77–0.95). Correlation between the LUS and CTSS was strong: κ = 0.60 (95% CI, 0.48–0.71). Conclusions We showed that baseline lung ultrasound ‐ is associated with poor outcomes, admission duration, and disease severity. The LUS also correlates well with CTSS. Point‐of‐care lung ultrasound may aid the risk stratification and triage of patients with COVID‐19 at the ED.https://doi.org/10.1002/emp2.12429COVID‐1930‐day mortalityICU admissionlung ultrasoundpneumoniapoint‐of‐care ultrasound |
| spellingShingle | Arthur W. E. Lieveld Bram Kok Kaoutar Azijli Frederik H. Schuit Peter M. van deVen Chris L. deKorte Robin Nijveldt Frederik M. A. vanden Heuvel Bernd P. Teunissen Wouter Hoefsloot Prabath W. B. Nanayakkara Frank H. Bosch Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational study Journal of the American College of Emergency Physicians Open COVID‐19 30‐day mortality ICU admission lung ultrasound pneumonia point‐of‐care ultrasound |
| title | Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational study |
| title_full | Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational study |
| title_fullStr | Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational study |
| title_full_unstemmed | Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational study |
| title_short | Assessing COVID‐19 pneumonia—Clinical extension and risk with point‐of‐care ultrasound: A multicenter, prospective, observational study |
| title_sort | assessing covid 19 pneumonia clinical extension and risk with point of care ultrasound a multicenter prospective observational study |
| topic | COVID‐19 30‐day mortality ICU admission lung ultrasound pneumonia point‐of‐care ultrasound |
| url | https://doi.org/10.1002/emp2.12429 |
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