Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer
Abstract Objective To analyze the factors related to the efficacy of neoadjuvant therapy for breast cancer and find appropriate evaluation methods for evaluating the efficacy of neoadjuvant therapy Methods A total of 143 patients with breast cancer treated by neoadjuvant chemotherapy at Baotou Cance...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-02998-8 |
| _version_ | 1797853773409812480 |
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| author | Xu Han Hui Li Sha-Sha Dong Shui-Ying Zhou Cai-Hong Wang Lin Guo Jie Yang Gang-Ling Zhang |
| author_facet | Xu Han Hui Li Sha-Sha Dong Shui-Ying Zhou Cai-Hong Wang Lin Guo Jie Yang Gang-Ling Zhang |
| author_sort | Xu Han |
| collection | DOAJ |
| description | Abstract Objective To analyze the factors related to the efficacy of neoadjuvant therapy for breast cancer and find appropriate evaluation methods for evaluating the efficacy of neoadjuvant therapy Methods A total of 143 patients with breast cancer treated by neoadjuvant chemotherapy at Baotou Cancer Hospital were retrospectively analyzed. The chemotherapy regimen was mainly paclitaxel combined with carboplatin for 1 week, docetaxel combined with carboplatin for 3 weeks, and was replaced with epirubicin combined with cyclophosphamide after evaluation of disease progression. All HER2-positive patients were treated with simultaneous targeted therapy, including trastuzumab single-target therapy and trastuzumab combined with pertuzumab double-target therapy. Combined with physical examination, color Doppler ultrasound, and magnetic resonance imaging (MRI), a systematic evaluation system was initially established—the “triple evaluation method.” A baseline evaluation was conducted before treatment. The efficacy was evaluated by physical examination and color Doppler every cycle, and the efficacy was evaluated by physical examination, color Doppler, and MRI every two cycles. Results The increase in ultrasonic blood flow after treatment could affect the efficacy of monitoring. The presence of two preoperative time–signal intensity curves is a therapeutically effective protective factor for inflow. The triple evaluation determined by physical examination, color Doppler ultrasound, and MRI in determining clinical efficacy is consistent with the effectiveness of the pathological gold standard. Conclusion The therapeutic effect of neoadjuvant therapy can be better evaluated by combining clinical physical examination, color ultrasound, and nuclear magnetic resonance evaluation. The three methods complement each other to avoid the insufficient evaluation of a single method, which is convenient for most prefecty-level hospitals. Additionally, this method is simple, feasible, and suitable for promotion. |
| first_indexed | 2024-04-09T19:55:04Z |
| format | Article |
| id | doaj.art-3e3afa43fbfa4741bca4934e009614fc |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-09T19:55:04Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-3e3afa43fbfa4741bca4934e009614fc2023-04-03T05:29:25ZengBMCWorld Journal of Surgical Oncology1477-78192023-03-012111910.1186/s12957-023-02998-8Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancerXu Han0Hui Li1Sha-Sha Dong2Shui-Ying Zhou3Cai-Hong Wang4Lin Guo5Jie Yang6Gang-Ling Zhang7Department of Breast Surgery, Baotou Cancer HospitalDepartment of Breast Surgery, Baotou Cancer HospitalDepartment of Breast Surgery, Baotou Cancer HospitalDepartment of Breast Surgery, Baotou Cancer HospitalDepartment of Operating Room, Baotou Cancer HospitalDepartment of Breast Surgery, Baotou Cancer HospitalDepartment of Breast Surgery, Baotou Cancer HospitalDepartment of Breast Surgery, Baotou Cancer HospitalAbstract Objective To analyze the factors related to the efficacy of neoadjuvant therapy for breast cancer and find appropriate evaluation methods for evaluating the efficacy of neoadjuvant therapy Methods A total of 143 patients with breast cancer treated by neoadjuvant chemotherapy at Baotou Cancer Hospital were retrospectively analyzed. The chemotherapy regimen was mainly paclitaxel combined with carboplatin for 1 week, docetaxel combined with carboplatin for 3 weeks, and was replaced with epirubicin combined with cyclophosphamide after evaluation of disease progression. All HER2-positive patients were treated with simultaneous targeted therapy, including trastuzumab single-target therapy and trastuzumab combined with pertuzumab double-target therapy. Combined with physical examination, color Doppler ultrasound, and magnetic resonance imaging (MRI), a systematic evaluation system was initially established—the “triple evaluation method.” A baseline evaluation was conducted before treatment. The efficacy was evaluated by physical examination and color Doppler every cycle, and the efficacy was evaluated by physical examination, color Doppler, and MRI every two cycles. Results The increase in ultrasonic blood flow after treatment could affect the efficacy of monitoring. The presence of two preoperative time–signal intensity curves is a therapeutically effective protective factor for inflow. The triple evaluation determined by physical examination, color Doppler ultrasound, and MRI in determining clinical efficacy is consistent with the effectiveness of the pathological gold standard. Conclusion The therapeutic effect of neoadjuvant therapy can be better evaluated by combining clinical physical examination, color ultrasound, and nuclear magnetic resonance evaluation. The three methods complement each other to avoid the insufficient evaluation of a single method, which is convenient for most prefecty-level hospitals. Additionally, this method is simple, feasible, and suitable for promotion.https://doi.org/10.1186/s12957-023-02998-8Breast cancerNeoadjuvant therapyTriple evaluation methodPhysical examinationColor Doppler ultrasoundMagnetic resonance imaging |
| spellingShingle | Xu Han Hui Li Sha-Sha Dong Shui-Ying Zhou Cai-Hong Wang Lin Guo Jie Yang Gang-Ling Zhang Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer World Journal of Surgical Oncology Breast cancer Neoadjuvant therapy Triple evaluation method Physical examination Color Doppler ultrasound Magnetic resonance imaging |
| title | Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer |
| title_full | Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer |
| title_fullStr | Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer |
| title_full_unstemmed | Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer |
| title_short | Application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer |
| title_sort | application of triple evaluation method in predicting the efficacy of neoadjuvant therapy for breast cancer |
| topic | Breast cancer Neoadjuvant therapy Triple evaluation method Physical examination Color Doppler ultrasound Magnetic resonance imaging |
| url | https://doi.org/10.1186/s12957-023-02998-8 |
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