High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome
Environmental factors are believed to influence the evolution of primary Sjögren’s syndrome (pSS). The aims of this study were to investigate the association of pSS with a high-fat diet (HFD) and to relate HFD-induced gut dysbiosis to pSS exacerbation. Male Wild Type (WT) and IL-14α transgenic mice...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.916089/full |
| _version_ | 1817969978340540416 |
|---|---|
| author | Minjie Zhang Minjie Zhang Yichen Liang Yichen Liang Yichen Liang Yanbo Liu Yanbo Liu Yanbo Liu Yanbo Liu Yixuan Li Yixuan Li Long Shen Long Shen Long Shen Guixiu Shi Guixiu Shi |
| author_facet | Minjie Zhang Minjie Zhang Yichen Liang Yichen Liang Yichen Liang Yanbo Liu Yanbo Liu Yanbo Liu Yanbo Liu Yixuan Li Yixuan Li Long Shen Long Shen Long Shen Guixiu Shi Guixiu Shi |
| author_sort | Minjie Zhang |
| collection | DOAJ |
| description | Environmental factors are believed to influence the evolution of primary Sjögren’s syndrome (pSS). The aims of this study were to investigate the association of pSS with a high-fat diet (HFD) and to relate HFD-induced gut dysbiosis to pSS exacerbation. Male Wild Type (WT) and IL-14α transgenic mice (IL-14α TG) were fed a standard diet (SD) and HFD for 11 months. We found an increase in the autoantibody level, more severe dry eye, severe dry mouth symptoms, and an earlier presence of systemic features in the IL-14α TG mice treated with HFD. These data suggest that HFD can promote the process of pSS in the IL-14α TG mice. In addition, an HFD leads to a decrease in the richness of gut microbiota of IL-14α TG mice treated with HFD. The abundance of Deferribacterota was significantly enriched in the IL-14α TG mice treated with HFD compared with other groups. Through the mental test between gut microbiota and clinical parameters, we found that HFD-induced dysbiosis gut microbiota were associated with pSS clinical parameters. In conclusion, HFD results in the aggravation of pSS progression, likely due to the increase of potentially pathogenic microorganisms. |
| first_indexed | 2024-04-13T20:28:24Z |
| format | Article |
| id | doaj.art-3e3b3b62f1554cffb4eb674796205226 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T20:28:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-3e3b3b62f1554cffb4eb6747962052262022-12-22T02:31:15ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-07-011310.3389/fmicb.2022.916089916089High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndromeMinjie Zhang0Minjie Zhang1Yichen Liang2Yichen Liang3Yichen Liang4Yanbo Liu5Yanbo Liu6Yanbo Liu7Yanbo Liu8Yixuan Li9Yixuan Li10Long Shen11Long Shen12Long Shen13Guixiu Shi14Guixiu Shi15Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, ChinaOncology Department, Northern Jiangsu People's Hospital, Yangzhou, ChinaCancer Institute Affiliated to Northern Jiangsu People's Hospital, Yangzhou, ChinaMedical College, Yangzhou University, Yangzhou, ChinaDepartment of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, ChinaEye Institute of Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, ChinaOncology Department, Northern Jiangsu People's Hospital, Yangzhou, ChinaCancer Institute Affiliated to Northern Jiangsu People's Hospital, Yangzhou, ChinaMedical College, Yangzhou University, Yangzhou, ChinaDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, ChinaEnvironmental factors are believed to influence the evolution of primary Sjögren’s syndrome (pSS). The aims of this study were to investigate the association of pSS with a high-fat diet (HFD) and to relate HFD-induced gut dysbiosis to pSS exacerbation. Male Wild Type (WT) and IL-14α transgenic mice (IL-14α TG) were fed a standard diet (SD) and HFD for 11 months. We found an increase in the autoantibody level, more severe dry eye, severe dry mouth symptoms, and an earlier presence of systemic features in the IL-14α TG mice treated with HFD. These data suggest that HFD can promote the process of pSS in the IL-14α TG mice. In addition, an HFD leads to a decrease in the richness of gut microbiota of IL-14α TG mice treated with HFD. The abundance of Deferribacterota was significantly enriched in the IL-14α TG mice treated with HFD compared with other groups. Through the mental test between gut microbiota and clinical parameters, we found that HFD-induced dysbiosis gut microbiota were associated with pSS clinical parameters. In conclusion, HFD results in the aggravation of pSS progression, likely due to the increase of potentially pathogenic microorganisms.https://www.frontiersin.org/articles/10.3389/fmicb.2022.916089/fullprimary Sjögren’s syndromehigh-fat dietgut microbiotalacrimal glandinflammation |
| spellingShingle | Minjie Zhang Minjie Zhang Yichen Liang Yichen Liang Yichen Liang Yanbo Liu Yanbo Liu Yanbo Liu Yanbo Liu Yixuan Li Yixuan Li Long Shen Long Shen Long Shen Guixiu Shi Guixiu Shi High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome Frontiers in Microbiology primary Sjögren’s syndrome high-fat diet gut microbiota lacrimal gland inflammation |
| title | High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome |
| title_full | High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome |
| title_fullStr | High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome |
| title_full_unstemmed | High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome |
| title_short | High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren’s syndrome |
| title_sort | high fat diet induced intestinal dysbiosis is associated with the exacerbation of sjogren s syndrome |
| topic | primary Sjögren’s syndrome high-fat diet gut microbiota lacrimal gland inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.916089/full |
| work_keys_str_mv | AT minjiezhang highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT minjiezhang highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yichenliang highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yichenliang highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yichenliang highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yanboliu highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yanboliu highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yanboliu highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yanboliu highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yixuanli highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT yixuanli highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT longshen highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT longshen highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT longshen highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT guixiushi highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome AT guixiushi highfatdietinducedintestinaldysbiosisisassociatedwiththeexacerbationofsjogrenssyndrome |